ID:TBA1C_HUMAN DESCRIPTION: RecName: Full=Tubulin alpha-1C chain; AltName: Full=Alpha-tubulin 6; AltName: Full=Tubulin alpha-6 chain; FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. SUBUNIT: Dimer of alpha and beta chains. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. PTM: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity). PTM: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable). PTM: Acetylation of alpha-tubulins at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity). SIMILARITY: Belongs to the tubulin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BQE3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK293589 - Homo sapiens cDNA FLJ55956 complete cds, highly similar to Tubulin alpha-6 chain. D28390 - Homo sapiens mRNA for tubulin alpha-1, 5'UTR region. BC005946 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:14580 IMAGE:4134187), complete cds. AK223024 - Homo sapiens mRNA for tubulin alpha 6 variant, clone: JTH01540. BC011790 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:19827 IMAGE:4025017), complete cds. BC063036 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:64889 IMAGE:4397636), complete cds. BC004949 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:10851 IMAGE:3617714), complete cds. BC033064 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:45598 IMAGE:3926854), complete cds. BC051297 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:59688 IMAGE:3832363), complete cds. BC019298 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:4112 IMAGE:2905506), complete cds. BC021088 - Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:1754 IMAGE:3543481), complete cds. CU678818 - Synthetic construct Homo sapiens gateway clone IMAGE:100019456 5' read TUBA1C mRNA. CU676808 - Synthetic construct Homo sapiens gateway clone IMAGE:100017294 5' read TUBA1C mRNA. CU675203 - Synthetic construct Homo sapiens gateway clone IMAGE:100017296 5' read TUBA1C mRNA. DQ896235 - Synthetic construct Homo sapiens clone IMAGE:100010695; FLH191421.01L; RZPDo839D0167D tubulin, alpha 6 (TUBA6) gene, encodes complete protein. DQ892986 - Synthetic construct clone IMAGE:100005616; FLH191425.01X; RZPDo839D0177D tubulin, alpha 6 (TUBA6) gene, encodes complete protein. KJ899828 - Synthetic construct Homo sapiens clone ccsbBroadEn_09222 TUBA1C gene, encodes complete protein. KJ906372 - Synthetic construct Homo sapiens clone ccsbBroadEn_16042 TUBA1C gene, encodes complete protein. KJ906373 - Synthetic construct Homo sapiens clone ccsbBroadEn_16043 TUBA1C gene, encodes complete protein. JD034886 - Sequence 15910 from Patent EP1572962. DL492088 - Novel nucleic acids. DL490632 - Novel nucleic acids. JD035670 - Sequence 16694 from Patent EP1572962. JD032220 - Sequence 13244 from Patent EP1572962. DQ589802 - Homo sapiens piRNA piR-56914, complete sequence. JD024485 - Sequence 5509 from Patent EP1572962. JD027061 - Sequence 8085 from Patent EP1572962. JD035518 - Sequence 16542 from Patent EP1572962. JD029285 - Sequence 10309 from Patent EP1572962. JD029721 - Sequence 10745 from Patent EP1572962. JD033115 - Sequence 14139 from Patent EP1572962. JD027868 - Sequence 8892 from Patent EP1572962. JD060811 - Sequence 41835 from Patent EP1572962. JD545462 - Sequence 526486 from Patent EP1572962. JD220127 - Sequence 201151 from Patent EP1572962. JD481273 - Sequence 462297 from Patent EP1572962. JD430912 - Sequence 411936 from Patent EP1572962. JD442902 - Sequence 423926 from Patent EP1572962. JD558728 - Sequence 539752 from Patent EP1572962. JD558727 - Sequence 539751 from Patent EP1572962. JD442901 - Sequence 423925 from Patent EP1572962. JD166446 - Sequence 147470 from Patent EP1572962. JD563479 - Sequence 544503 from Patent EP1572962. JD508277 - Sequence 489301 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BQE3 (Reactome details) participates in the following event(s):
R-HSA-389980 unfolded actin/tubulin associates with prefoldin R-HSA-389970 Actin/tubulin:prefoldin complex associates with CCT/TriC R-HSA-389954 Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC R-HSA-389961 ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex R-HSA-389972 alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B R-HSA-389978 alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E R-HSA-389974 Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi R-HSA-8955712 TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin R-HSA-8955706 TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin R-HSA-389963 alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B R-HSA-389976 Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E R-HSA-389964 Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC R-HSA-389977 Post-chaperonin tubulin folding pathway R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
