Human Gene TUBA3D (ENST00000321253.7_4) from GENCODE V47lift37
  Description: tubulin alpha 3d (from RefSeq NM_080386.4)
Gencode Transcript: ENST00000321253.7_4
Gencode Gene: ENSG00000075886.11_7
Transcript (Including UTRs)
   Position: hg19 chr2:132,233,692-132,240,507 Size: 6,816 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr2:132,233,773-132,240,421 Size: 6,649 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:132,233,692-132,240,507)mRNA (may differ from genome)Protein (450 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q1ZYQ1_HUMAN
DESCRIPTION: SubName: Full=Tubulin, alpha 2; SubName: Full=Tubulin, alpha 2, isoform CRA_b; SubName: Full=cDNA FLJ77591, highly similar to Homo sapiens tubulin, alpha 2 (TUBA2), transcript variant 1, mRNA;
FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).
SUBUNIT: Dimer of alpha and beta chains (By similarity).
SIMILARITY: Belongs to the tubulin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TUBA3D
Diseases sorted by gene-association score: congenital nervous system abnormality (2), ectodermal dysplasia 2, clouston type (2), heterotopia, periventricular (1), physical disorder (1), epileptic encephalopathy, early infantile, 15 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 205.15 RPKM in Testis
Total median expression: 251.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.2081-0.373 Picture PostScript Text
3' UTR -25.3086-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002452 - Alpha_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR023123 - Tubulin_C
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase

Pfam Domains:
PF00091 - Tubulin/FtsZ family, GTPase domain
PF03953 - Tubulin C-terminal domain

SCOP Domains:
52490 - Tubulin nucleotide-binding domain-like
53474 - alpha/beta-Hydrolases
55307 - Tubulin C-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q1ZYQ1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

Biological Process:
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK093116 - Homo sapiens cDNA FLJ35797 fis, clone TESTI2005892, highly similar to TUBULIN ALPHA-3/ALPHA-7 CHAIN.
AX747933 - Sequence 1458 from Patent EP1308459.
JD538162 - Sequence 519186 from Patent EP1572962.
JD462609 - Sequence 443633 from Patent EP1572962.
JD478306 - Sequence 459330 from Patent EP1572962.
JD461773 - Sequence 442797 from Patent EP1572962.
JD406622 - Sequence 387646 from Patent EP1572962.
JD461062 - Sequence 442086 from Patent EP1572962.
AK292253 - Homo sapiens cDNA FLJ77591 complete cds, highly similar to Homo sapiens tubulin, alpha 2 (TUBA2), transcript variant 1, mRNA.
BC057810 - Homo sapiens tubulin, alpha 3d, mRNA (cDNA clone MGC:71736 IMAGE:5268074), complete cds.
HQ448562 - Synthetic construct Homo sapiens clone IMAGE:100071998; CCSB010952_04 tubulin, alpha 3d (TUBA3D) gene, encodes complete protein.
KJ899992 - Synthetic construct Homo sapiens clone ccsbBroadEn_09386 TUBA3D gene, encodes complete protein.
CU691248 - Synthetic construct Homo sapiens gateway clone IMAGE:100021189 5' read TUBA3D mRNA.
JD341729 - Sequence 322753 from Patent EP1572962.
JD395537 - Sequence 376561 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000321253.1, ENST00000321253.2, ENST00000321253.3, ENST00000321253.4, ENST00000321253.5, ENST00000321253.6, hCG_19100 , NM_080386, Q1ZYQ1, Q1ZYQ1_HUMAN, TUBA2 , uc317rag.1, uc317rag.2
UCSC ID: ENST00000321253.7_4
RefSeq Accession: NM_080386.4
Protein: Q1ZYQ1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.