Human Gene TUBAL3 (ENST00000380419.8_7) from GENCODE V47lift37
  Description: tubulin alpha like 3, transcript variant 1 (from RefSeq NM_024803.3)
Gencode Transcript: ENST00000380419.8_7
Gencode Gene: ENSG00000178462.12_9
Transcript (Including UTRs)
   Position: hg19 chr10:5,435,064-5,446,791 Size: 11,728 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr10:5,435,480-5,446,755 Size: 11,276 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:5,435,064-5,446,791)mRNA (may differ from genome)Protein (446 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TBAL3_HUMAN
DESCRIPTION: RecName: Full=Tubulin alpha chain-like 3;
FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
SIMILARITY: Belongs to the tubulin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.93 RPKM in Small Intestine - Terminal Ileum
Total median expression: 26.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.3036-0.064 Picture PostScript Text
3' UTR -106.80416-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002452 - Alpha_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR023123 - Tubulin_C
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase

Pfam Domains:
PF00091 - Tubulin/FtsZ family, GTPase domain
PF03953 - Tubulin C-terminal domain

SCOP Domains:
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like

ModBase Predicted Comparative 3D Structure on A6NHL2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

Biological Process:
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule


-  Descriptions from all associated GenBank mRNAs
  KJ894745 - Synthetic construct Homo sapiens clone ccsbBroadEn_04139 TUBAL3 gene, encodes complete protein.
KJ899576 - Synthetic construct Homo sapiens clone ccsbBroadEn_08970 TUBAL3 gene, encodes complete protein.
AK025318 - Homo sapiens cDNA: FLJ21665 fis, clone COL08913.
JD066478 - Sequence 47502 from Patent EP1572962.
BC098247 - Homo sapiens tubulin, alpha-like 3, mRNA (cDNA clone MGC:119346 IMAGE:40005930), complete cds.
BC099716 - Homo sapiens tubulin, alpha-like 3, mRNA (cDNA clone MGC:119349 IMAGE:40005934), complete cds.
BC105634 - Homo sapiens tubulin, alpha-like 3, mRNA (cDNA clone MGC:119347 IMAGE:40005931), complete cds.
AK296616 - Homo sapiens cDNA FLJ55145 complete cds, highly similar to Homo sapiens tubulin, alpha-like 3 (TUBAL3), mRNA.
JD283996 - Sequence 265020 from Patent EP1572962.
JD343620 - Sequence 324644 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein A6NHL2 (Reactome details) participates in the following event(s):

R-HSA-389972 alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B
R-HSA-389978 alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E
R-HSA-389954 Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC
R-HSA-389961 ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex
R-HSA-389974 Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi
R-HSA-389963 alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B
R-HSA-389976 Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E
R-HSA-389964 Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C
R-HSA-389977 Post-chaperonin tubulin folding pathway
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-391251 Protein folding
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-392499 Metabolism of proteins
R-HSA-390466 Chaperonin-mediated protein folding

-  Other Names for This Gene
  Alternate Gene Symbols: A6NHL2, B4DKL2, ENST00000380419.1, ENST00000380419.2, ENST00000380419.3, ENST00000380419.4, ENST00000380419.5, ENST00000380419.6, ENST00000380419.7, NM_024803, Q4QQJ5, Q9H6Z0, TBAL3_HUMAN, uc318pot.1, uc318pot.2
UCSC ID: ENST00000380419.8_7
RefSeq Accession: NM_024803.3
Protein: A6NHL2 (aka TBAL3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.