Human Gene TUBB (ENST00000327892.13_4) from GENCODE V47lift37
Description: tubulin beta class I, transcript variant 7 (from RefSeq NR_120608.2)Gencode Transcript: ENST00000327892.13_4Gencode Gene: ENSG00000196230.14_8Transcript (Including UTRs) Position: hg19 chr6:30,688,129-30,693,199 Size: 5,071 Total Exon Count: 4 Strand: +Coding Region Position: hg19 chr6:30,688,284-30,692,174 Size: 3,891 Coding Exon Count: 4
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: Q5SU16_HUMAN DESCRIPTION: SubName: Full=Beta 5-tubulin; SubName: Full=Beta-tubulin protein; SubName: Full=Tubulin beta polypeptide; SubName: Full=Tubulin, beta; SubName: Full=Tubulin, beta, isoform CRA_a;FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).SUBUNIT: Dimer of alpha and beta chains (By similarity).SIMILARITY: Belongs to the tubulin family.
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: TUBB
Diseases sorted by gene-association score: cortical dysplasia, complex, with other brain malformations 6 * (1342), symmetric circumferential skin creases, congenital, 1 * (1200), multiple benign circumferential skin creases on limbs * (750), dementia, familial danish (13), lung mucoepidermoid carcinoma (9), dementia, familial british (9), giant axonal neuropathy (8), distal hereditary motor neuropathy, type ii (7), charcot-marie-tooth disease, axonal, type 2k (5), microcephaly (2), intellectual disability (2), ovarian cancer, somatic (1), leber congenital amaurosis (1)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
C517041
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
C016614
1-nitronaphthalene
C511295
2,2,4,4-tetrabromodiphenyl ether
C029497
2,3-bis(3'-hydroxybenzyl)butyrolactone
C440850
2,4,3',5'-tetramethoxystilbene
C030370
2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
C547126
AZM551248
D000117
Acetylglucosamine
D000643
Ammonium Chloride
D001151
Arsenic
D001280
Atrazine
D001562
Benzimidazoles
D001564
Benzo(a)pyrene
D002330
Carmustine
D002945
Cisplatin
D003300
Copper
D003375
Coumestrol
D016572
Cyclosporine
D003687
Dehydroepiandrosterone
D004006
Dichlorvos
D004052
Diethylnitrosamine
D004237
Diuron
D004317
Doxorubicin
D004958
Estradiol
D017313
Fenretinide
D005472
Fluorouracil
D019833
Genistein
D018684
Glycine Agents
D007529
Isoflavones
D008767
Methylmercury Compounds
D015741
Metribolone
D009538
Nicotine
D017239
Paclitaxel
D011374
Progesterone
D011794
Quercetin
D012643
Selenium
D013759
Tetrahydrocannabinol
D019284
Thapsigargin
D014028
Tobacco Smoke Pollution
D014635
Valproic Acid
D014810
Vitamin E
D019324
beta-Naphthoflavone
C044887
beta-methylcholine
C004541
biochanin A
C006780
bisphenol A
C028031
cadmium acetate
C018021
cobaltous chloride
C049098
diallyl phthalate
C067311
docetaxel
C001654
hyperforin
C028904
isoproturon
C031721
naphthalene
C006253
pirinixic acid
C422648
pluronic block copolymer p85
C010327
salinomycin
C017947
sodium arsenite
C009495
titanium dioxide
C012589
trichostatin A
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR013838 - Beta-tubulin_BSIPR002453 - Beta_tubulinIPR008280 - Tub_FtsZ_CIPR000217 - TubulinIPR018316 - Tubulin/FtsZ_2-layer-sand-domIPR023123 - Tubulin_CIPR017975 - Tubulin_CSIPR003008 - Tubulin_FtsZ_GTPasePfam Domains: PF00091 - Tubulin/FtsZ family, GTPase domainPF03953 - Tubulin C-terminal domainSCOP Domains: 52490 - Tubulin nucleotide-binding domain-like55307 - Tubulin C-terminal domain-likeModBase Predicted Comparative 3D Structure on Q5SU16 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
KJ904004 - Synthetic construct Homo sapiens clone ccsbBroadEn_13398 TUBB gene, encodes complete protein.JD392135 - Sequence 373159 from Patent EP1572962.AK303227 - Homo sapiens cDNA FLJ52378 complete cds, highly similar to Tubulin beta-7 chain.BC020946 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:26663 IMAGE:4795692), complete cds.AK302195 - Homo sapiens cDNA FLJ52029 complete cds, highly similar to Tubulin beta-7 chain.AK297638 - Homo sapiens cDNA FLJ53063 complete cds, highly similar to Tubulin beta-7 chain.BC085007 - Homo sapiens cDNA clone IMAGE:6598943, **** WARNING: chimeric clone ****.AK316265 - Homo sapiens cDNA, FLJ79164 complete cds, highly similar to Tubulin beta-7 chain.AK098772 - Homo sapiens cDNA FLJ25906 fis, clone CBR04603, highly similar to TUBULIN BETA-5 CHAIN.BC103746 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:117247 IMAGE:6503977), complete cds.AF141349 - Homo sapiens beta-tubulin mRNA, complete cds.AF070600 - Homo sapiens clone 24464 beta-tubulin mRNA, complete cds.BC070326 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:88329 IMAGE:6698679), complete cds.BC002347 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:8668 IMAGE:2964461), complete cds.BC007605 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:15683 IMAGE:3350604), complete cds.JD409981 - Sequence 391005 from Patent EP1572962.AB062393 - Homo sapiens OK/SW-cl.56 mRNA for beta 5-tubulin, complete cds.JD235968 - Sequence 216992 from Patent EP1572962.BC001938 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:4101 IMAGE:2820585), complete cds.BC005838 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:2440 IMAGE:2820585), complete cds.JD292485 - Sequence 273509 from Patent EP1572962.JD445615 - Sequence 426639 from Patent EP1572962.AF070561 - Homo sapiens clone 24703 beta-tubulin mRNA, complete cds.AF070593 - Homo sapiens clones 24609 and 24716 beta-tubulin mRNA, complete cds.BC013374 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:16435 IMAGE:3946253), complete cds.BC021909 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:15853 IMAGE:3509417), complete cds.BC019924 - Homo sapiens tubulin, beta, mRNA (cDNA clone MGC:30201 IMAGE:4998571), complete cds.BC062532 - Homo sapiens tubulin, beta, mRNA (cDNA clone IMAGE:3637650), complete cds.JD544113 - Sequence 525137 from Patent EP1572962.AK297489 - Homo sapiens cDNA FLJ53012 complete cds, highly similar to Tubulin beta-7 chain.JD300450 - Sequence 281474 from Patent EP1572962.DQ599097 - Homo sapiens piRNA piR-37163, complete sequence.DQ891742 - Synthetic construct clone IMAGE:100004372; FLH180257.01X; RZPDo839A03134D tubulin, beta (TUBB) gene, encodes complete protein.DQ891828 - Synthetic construct Homo sapiens clone IMAGE:100004458; FLH263550.01X; RZPDo839B02134D tubulin, beta (TUBB) gene, encodes complete protein.DQ894920 - Synthetic construct Homo sapiens clone IMAGE:100009380; FLH180253.01L; RZPDo839A03133D tubulin, beta (TUBB) gene, encodes complete protein.AB463327 - Synthetic construct DNA, clone: pF1KB9038, Homo sapiens TBB5 gene for Tubulin beta chain, without stop codon, in Flexi system.CU676482 - Synthetic construct Homo sapiens gateway clone IMAGE:100019426 5' read TUBB mRNA.KJ895812 - Synthetic construct Homo sapiens clone ccsbBroadEn_05206 TUBB gene, encodes complete protein.GQ900970 - Homo sapiens clone HEL-T-82 epididymis secretory sperm binding protein mRNA, partial cds.V00599 - Human mRNA fragment encoding beta-tubulin. (from clone D-beta-1).LF210809 - JP 2014500723-A/18312: Polycomb-Associated Non-Coding RNAs.AK298889 - Homo sapiens cDNA FLJ50617 complete cds, highly similar to Tubulin beta-7 chain.AK316316 - Homo sapiens cDNA, FLJ79215 complete cds, highly similar to Tubulin beta-7 chain.AK302314 - Homo sapiens cDNA FLJ56903 complete cds, highly similar to Tubulin beta-7 chain.LF341324 - JP 2014500723-A/148827: Polycomb-Associated Non-Coding RNAs.Z36874 - H.sapiens (xs127) mRNA, 106bp.LF341322 - JP 2014500723-A/148825: Polycomb-Associated Non-Coding RNAs.AK309684 - Homo sapiens cDNA, FLJ99725.BC001896 - Homo sapiens tubulin, beta, mRNA (cDNA clone IMAGE:3544415), partial cds.LF341321 - JP 2014500723-A/148824: Polycomb-Associated Non-Coding RNAs.LF341319 - JP 2014500723-A/148822: Polycomb-Associated Non-Coding RNAs.DQ457058 - Homo sapiens XTP3TPA-transactivated protein 1 (XTP3TPATP1) mRNA, XTP3TPATP1-S allele, complete cds.BC029323 - Homo sapiens tubulin, beta, mRNA (cDNA clone IMAGE:4705792).BC015889 - Homo sapiens tubulin, beta, mRNA (cDNA clone IMAGE:3922098), partial cds.JD022558 - Sequence 3582 from Patent EP1572962.JD035170 - Sequence 16194 from Patent EP1572962.LF341318 - JP 2014500723-A/148821: Polycomb-Associated Non-Coding RNAs.DQ595633 - Homo sapiens piRNA piR-61745, complete sequence.LF341317 - JP 2014500723-A/148820: Polycomb-Associated Non-Coding RNAs.LF341316 - JP 2014500723-A/148819: Polycomb-Associated Non-Coding RNAs.DQ584144 - Homo sapiens piRNA piR-51256, complete sequence.CU687552 - Synthetic construct Homo sapiens gateway clone IMAGE:100023005 5' read TUBB mRNA.DQ580576 - Homo sapiens piRNA piR-48688, complete sequence.JD069440 - Sequence 50464 from Patent EP1572962.DQ578159 - Homo sapiens piRNA piR-46271, complete sequence.BC001002 - Homo sapiens tubulin, beta, mRNA (cDNA clone IMAGE:3447696).EF036509 - Homo sapiens beta-4 tubulin mRNA, partial cds.JD066379 - Sequence 47403 from Patent EP1572962.JD224388 - Sequence 205412 from Patent EP1572962.JD190991 - Sequence 172015 from Patent EP1572962.JD412324 - Sequence 393348 from Patent EP1572962.JD060024 - Sequence 41048 from Patent EP1572962.JD506890 - Sequence 487914 from Patent EP1572962.JD345791 - Sequence 326815 from Patent EP1572962.JD345792 - Sequence 326816 from Patent EP1572962.JD241909 - Sequence 222933 from Patent EP1572962.JD241910 - Sequence 222934 from Patent EP1572962.JD076314 - Sequence 57338 from Patent EP1572962.JD235731 - Sequence 216755 from Patent EP1572962.JD120231 - Sequence 101255 from Patent EP1572962.JD491318 - Sequence 472342 from Patent EP1572962.JD402371 - Sequence 383395 from Patent EP1572962.JD308374 - Sequence 289398 from Patent EP1572962.JD564867 - Sequence 545891 from Patent EP1572962.MA446386 - JP 2018138019-A/18312: Polycomb-Associated Non-Coding RNAs.MA576901 - JP 2018138019-A/148827: Polycomb-Associated Non-Coding RNAs.MA576899 - JP 2018138019-A/148825: Polycomb-Associated Non-Coding RNAs.MA576898 - JP 2018138019-A/148824: Polycomb-Associated Non-Coding RNAs.MA576896 - JP 2018138019-A/148822: Polycomb-Associated Non-Coding RNAs.MA576895 - JP 2018138019-A/148821: Polycomb-Associated Non-Coding RNAs.MA576894 - JP 2018138019-A/148820: Polycomb-Associated Non-Coding RNAs.MA576893 - JP 2018138019-A/148819: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: ENST00000327892.1, ENST00000327892.10, ENST00000327892.11, ENST00000327892.12, ENST00000327892.2, ENST00000327892.3, ENST00000327892.4, ENST00000327892.5, ENST00000327892.6, ENST00000327892.7, ENST00000327892.8, ENST00000327892.9, hCG_26016 , NR_120608, OK/SW-cl.56 , Q5SU16, Q5SU16_HUMAN, TUBB , uc317sjq.1, uc317sjq.2UCSC ID: ENST00000327892.13_4RefSeq Accession: NM_178014.4 Protein: Q5SU16
GeneReviews for This Gene
GeneReviews article(s) related to gene TUBB:tubulin-ov
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
