Human Gene TUBGCP3 (ENST00000261965.8_7) from GENCODE V47lift37
  Description: tubulin gamma complex associated protein 3, transcript variant 1 (from RefSeq NM_006322.6)
Gencode Transcript: ENST00000261965.8_7
Gencode Gene: ENSG00000126216.15_11
Transcript (Including UTRs)
   Position: hg19 chr13:113,139,325-113,242,467 Size: 103,143 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr13:113,140,307-113,242,294 Size: 101,988 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:113,139,325-113,242,467)mRNA (may differ from genome)Protein (907 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GCP3_HUMAN
DESCRIPTION: RecName: Full=Gamma-tubulin complex component 3; Short=GCP-3; Short=hGCP3; AltName: Full=Gamma-ring complex protein 104 kDa; Short=h104p; Short=hGrip104; AltName: Full=Spindle pole body protein Spc98 homolog; Short=hSpc98;
FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
SUBUNIT: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome.
TISSUE SPECIFICITY: Ubiquitously expressed.
SIMILARITY: Belongs to the TUBGCP family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TUBGCP3
Diseases sorted by gene-association score: cardiomyopathy, dilated, 1p (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.14 RPKM in Testis
Total median expression: 309.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -94.20173-0.545 Picture PostScript Text
3' UTR -229.70982-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015697 - GCP3
IPR007259 - Spc97_Spc98

Pfam Domains:
PF04130 - Gamma tubulin complex component C-terminal
PF17681 - Gamma tubulin complex component N-terminal

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q96CW5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0043015 gamma-tubulin binding
GO:0051011 microtubule minus-end binding

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0007020 microtubule nucleation
GO:0007338 single fertilization
GO:0031122 cytoplasmic microtubule organization
GO:0051298 centrosome duplication
GO:0051321 meiotic cell cycle
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center
GO:0090307 mitotic spindle assembly

Cellular Component:
GO:0000922 spindle pole
GO:0000923 equatorial microtubule organizing center
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005827 polar microtubule
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0008275 gamma-tubulin small complex
GO:0016020 membrane
GO:0005816 spindle pole body


-  Descriptions from all associated GenBank mRNAs
  L13800 - Homo sapiens liver expressed protein gene, 3' end.
AF042378 - Homo sapiens spindle pole body protein spc98 homolog GCP3 mRNA, complete cds.
BC046634 - Homo sapiens tubulin, gamma complex associated protein 3, mRNA (cDNA clone MGC:44333 IMAGE:5295831), complete cds.
LF384331 - JP 2014500723-A/191834: Polycomb-Associated Non-Coding RNAs.
LF371263 - JP 2014500723-A/178766: Polycomb-Associated Non-Coding RNAs.
JD082983 - Sequence 64007 from Patent EP1572962.
JD302451 - Sequence 283475 from Patent EP1572962.
JD302691 - Sequence 283715 from Patent EP1572962.
JD553799 - Sequence 534823 from Patent EP1572962.
JD245133 - Sequence 226157 from Patent EP1572962.
L13801 - Homo sapiens (clone 02) liver expressed protein similar to pig hepatic protein (descibed in M29509) mRNA fragment.
AK302537 - Homo sapiens cDNA FLJ55435 complete cds, highly similar to Gamma-tubulin complex component 3.
JD456687 - Sequence 437711 from Patent EP1572962.
JD101039 - Sequence 82063 from Patent EP1572962.
JD051421 - Sequence 32445 from Patent EP1572962.
AJ003061 - Homo sapiens mRNA for protein encoded by Saccharomyces cerevisiae SPC98 homologue.
AK314785 - Homo sapiens cDNA, FLJ95655, Homo sapiens tubulin, gamma complex associated protein 3 (TUBGCP3), mRNA.
AB384386 - Synthetic construct DNA, clone: pF1KSDB0060, Homo sapiens TUBGCP3 gene for gamma-tubulin complex component 3, complete cds, without stop codon, in Flexi system.
JD494450 - Sequence 475474 from Patent EP1572962.
BC013781 - Homo sapiens tubulin, gamma complex associated protein 3, mRNA (cDNA clone MGC:9866 IMAGE:3867019), complete cds.
AJ003062 - Homo sapiens mRNA for protein encoded by Saccharomyces cerevisiae SPC98 homologue.
KJ902103 - Synthetic construct Homo sapiens clone ccsbBroadEn_11497 TUBGCP3 gene, encodes complete protein.
BT009772 - Homo sapiens tubulin, gamma complex associated protein 3 mRNA, complete cds.
DQ891072 - Synthetic construct clone IMAGE:100003702; FLH169078.01X; RZPDo839G0394D tubulin, gamma complex associated protein 3 (TUBGCP3) gene, encodes complete protein.
DQ894255 - Synthetic construct Homo sapiens clone IMAGE:100008715; FLH169074.01L; RZPDo839G0393D tubulin, gamma complex associated protein 3 (TUBGCP3) gene, encodes complete protein.
LF371264 - JP 2014500723-A/178767: Polycomb-Associated Non-Coding RNAs.
BC007763 - Homo sapiens tubulin, gamma complex associated protein 3, mRNA (cDNA clone IMAGE:4137255), complete cds.
KJ902102 - Synthetic construct Homo sapiens clone ccsbBroadEn_11496 TUBGCP3 gene, encodes complete protein.
CU680680 - Synthetic construct Homo sapiens gateway clone IMAGE:100020428 5' read TUBGCP3 mRNA.
LF371273 - JP 2014500723-A/178776: Polycomb-Associated Non-Coding RNAs.
LF371275 - JP 2014500723-A/178778: Polycomb-Associated Non-Coding RNAs.
JD073097 - Sequence 54121 from Patent EP1572962.
JD514839 - Sequence 495863 from Patent EP1572962.
JD429458 - Sequence 410482 from Patent EP1572962.
MA619908 - JP 2018138019-A/191834: Polycomb-Associated Non-Coding RNAs.
MA606840 - JP 2018138019-A/178766: Polycomb-Associated Non-Coding RNAs.
MA606841 - JP 2018138019-A/178767: Polycomb-Associated Non-Coding RNAs.
MA606850 - JP 2018138019-A/178776: Polycomb-Associated Non-Coding RNAs.
MA606852 - JP 2018138019-A/178778: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96CW5 (Reactome details) participates in the following event(s):

R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-HSA-380508 Translocation of NuMA to the centrosomes
R-HSA-380316 Association of NuMA with microtubules
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-380287 Centrosome maturation
R-HSA-68877 Mitotic Prometaphase
R-HSA-69275 G2/M Transition
R-HSA-68886 M Phase
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000261965.1, ENST00000261965.2, ENST00000261965.3, ENST00000261965.4, ENST00000261965.5, ENST00000261965.6, ENST00000261965.7, GCP3, GCP3_HUMAN, NM_006322, O43631, O60852, O60853, Q5T8L2, Q7Z4K1, Q96CW5, Q96I79, uc317gvq.1, uc317gvq.2
UCSC ID: ENST00000261965.8_7
RefSeq Accession: NM_006322.6
Protein: Q96CW5 (aka GCP3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.