Human Gene TUBGCP5 (ENST00000615383.5_8) from GENCODE V47lift37
  Description: tubulin gamma complex associated protein 5, transcript variant 1 (from RefSeq NM_052903.6)
Gencode Transcript: ENST00000615383.5_8
Gencode Gene: ENSG00000275835.5_17
Transcript (Including UTRs)
   Position: hg19 chr15:22,833,499-22,873,891 Size: 40,393 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg19 chr15:22,833,525-22,873,248 Size: 39,724 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:22,833,499-22,873,891)mRNA (may differ from genome)Protein (1024 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GCP5_HUMAN
DESCRIPTION: RecName: Full=Gamma-tubulin complex component 5; Short=GCP-5;
FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
SUBUNIT: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome.
TISSUE SPECIFICITY: Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.
SIMILARITY: Belongs to the TUBGCP family.
SEQUENCE CAUTION: Sequence=AAH46182.1; Type=Erroneous initiation; Sequence=BAB67792.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.9026-0.419 Picture PostScript Text
3' UTR -186.90643-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007259 - Spc97_Spc98

Pfam Domains:
PF04130 - Gamma tubulin complex component C-terminal
PF17681 - Gamma tubulin complex component N-terminal

ModBase Predicted Comparative 3D Structure on Q96RT8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005200 structural constituent of cytoskeleton
GO:0008017 microtubule binding
GO:0043015 gamma-tubulin binding
GO:0051011 microtubule minus-end binding

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0007020 microtubule nucleation
GO:0031122 cytoplasmic microtubule organization
GO:0051298 centrosome duplication
GO:0051321 meiotic cell cycle
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center
GO:0090307 mitotic spindle assembly

Cellular Component:
GO:0000922 spindle pole
GO:0000923 equatorial microtubule organizing center
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0008274 gamma-tubulin ring complex
GO:0005816 spindle pole body


-  Descriptions from all associated GenBank mRNAs
  KJ900005 - Synthetic construct Homo sapiens clone ccsbBroadEn_09399 TUBGCP5 gene, encodes complete protein.
LF384275 - JP 2014500723-A/191778: Polycomb-Associated Non-Coding RNAs.
BC039271 - Homo sapiens cDNA clone IMAGE:5298568, containing frame-shift errors.
AF272884 - Homo sapiens gamma-tubulin complex component GCP5 (GCP5) mRNA, complete cds.
AB067486 - Homo sapiens mRNA for KIAA1899 protein.
AK056416 - Homo sapiens cDNA FLJ31854 fis, clone NT2RP7000906, weakly similar to Medicago truncatula mRNA for 85p protein (85p gene).
AK289859 - Homo sapiens cDNA FLJ77411 complete cds, highly similar to Homo sapiens gamma-tubulin complex component GCP5 (GCP5) mRNA.
AK310897 - Homo sapiens cDNA, FLJ17939.
BC071560 - Homo sapiens tubulin, gamma complex associated protein 5, mRNA (cDNA clone MGC:86996 IMAGE:5297149), complete cds.
AB384320 - Synthetic construct DNA, clone: pF1KSDA1899, Homo sapiens TUBGCP5 gene for gamma-tubulin complex component 5, complete cds, without stop codon, in Flexi system.
LF368070 - JP 2014500723-A/175573: Polycomb-Associated Non-Coding RNAs.
LF368071 - JP 2014500723-A/175574: Polycomb-Associated Non-Coding RNAs.
LF368072 - JP 2014500723-A/175575: Polycomb-Associated Non-Coding RNAs.
LF368073 - JP 2014500723-A/175576: Polycomb-Associated Non-Coding RNAs.
AK023934 - Homo sapiens cDNA FLJ13872 fis, clone THYRO1001322.
LF368074 - JP 2014500723-A/175577: Polycomb-Associated Non-Coding RNAs.
LF368077 - JP 2014500723-A/175580: Polycomb-Associated Non-Coding RNAs.
BC046182 - Homo sapiens tubulin, gamma complex associated protein 5, mRNA (cDNA clone IMAGE:5175880), complete cds.
LF368078 - JP 2014500723-A/175581: Polycomb-Associated Non-Coding RNAs.
JD492891 - Sequence 473915 from Patent EP1572962.
JD249012 - Sequence 230036 from Patent EP1572962.
JD179277 - Sequence 160301 from Patent EP1572962.
JD279395 - Sequence 260419 from Patent EP1572962.
JD193654 - Sequence 174678 from Patent EP1572962.
JD134120 - Sequence 115144 from Patent EP1572962.
JD421095 - Sequence 402119 from Patent EP1572962.
JD532242 - Sequence 513266 from Patent EP1572962.
JD442937 - Sequence 423961 from Patent EP1572962.
JD335342 - Sequence 316366 from Patent EP1572962.
LF368079 - JP 2014500723-A/175582: Polycomb-Associated Non-Coding RNAs.
MA619852 - JP 2018138019-A/191778: Polycomb-Associated Non-Coding RNAs.
MA603647 - JP 2018138019-A/175573: Polycomb-Associated Non-Coding RNAs.
MA603648 - JP 2018138019-A/175574: Polycomb-Associated Non-Coding RNAs.
MA603649 - JP 2018138019-A/175575: Polycomb-Associated Non-Coding RNAs.
MA603650 - JP 2018138019-A/175576: Polycomb-Associated Non-Coding RNAs.
MA603651 - JP 2018138019-A/175577: Polycomb-Associated Non-Coding RNAs.
MA603654 - JP 2018138019-A/175580: Polycomb-Associated Non-Coding RNAs.
MA603655 - JP 2018138019-A/175581: Polycomb-Associated Non-Coding RNAs.
MA603656 - JP 2018138019-A/175582: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96RT8 (Reactome details) participates in the following event(s):

R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-HSA-380508 Translocation of NuMA to the centrosomes
R-HSA-380316 Association of NuMA with microtubules
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-380287 Centrosome maturation
R-HSA-68877 Mitotic Prometaphase
R-HSA-69275 G2/M Transition
R-HSA-68886 M Phase
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: E9PB12, ENST00000615383.1, ENST00000615383.2, ENST00000615383.3, ENST00000615383.4, GCP5, GCP5_HUMAN, KIAA1899, NM_052903, Q6IQ52, Q96PY8, Q96RT8, uc327pvv.1, uc327pvv.2
UCSC ID: ENST00000615383.5_8
RefSeq Accession: NM_052903.6
Protein: Q96RT8 (aka GCP5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.