ID:TWF2_HUMAN DESCRIPTION: RecName: Full=Twinfilin-2; AltName: Full=A6-related protein; Short=hA6RP; AltName: Full=Protein tyrosine kinase 9-like; AltName: Full=Twinfilin-1-like protein; FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). SUBUNIT: Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF1 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down- regulated. Interacts with MYO7A (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, stereocilium (By similarity). Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. TISSUE SPECIFICITY: Ubiquitously expressed (at protein level). PTM: In vitro, phosphorylated by PRKCZ, CK2 and SRC. SIMILARITY: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. SIMILARITY: Contains 2 ADF-H domains. WEB RESOURCE: Name=Protein Spotlight; Note=Molecular embrace - Issue 73 of August 2006; URL="http://web.expasy.org/spotlight/back_issues/sptlt073.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6IBS0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
