Human Gene UBA52 (ENST00000442744.7_4) from GENCODE V47lift37
  Description: ubiquitin A-52 residue ribosomal protein fusion product 1, transcript variant 2 (from RefSeq NM_003333.5)
Gencode Transcript: ENST00000442744.7_4
Gencode Gene: ENSG00000221983.8_14
Transcript (Including UTRs)
   Position: hg19 chr19:18,682,667-18,688,360 Size: 5,694 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr19:18,684,111-18,685,960 Size: 1,850 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:18,682,667-18,688,360)mRNA (may differ from genome)Protein (128 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: UBA52
Diseases sorted by gene-association score: stomatitis (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • D003300 Copper
  • D013749 Tetrachlorodibenzodioxin
  • C006780 bisphenol A
  • C049325 1,2-dithiol-3-thione
  • C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • C009505 4,4'-diaminodiphenylmethane
  • C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • D000638 Amiodarone
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 262.85 RPKM in Whole Blood
Total median expression: 5931.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.0061-0.311 Picture PostScript Text
3' UTR -850.902400-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001975 - Ribosomal_L40e
IPR000626 - Ubiquitin
IPR019954 - Ubiquitin_CS
IPR019956 - Ubiquitin_subgr
IPR019955 - Ubiquitin_supergroup

Pfam Domains:
PF00240 - Ubiquitin family
PF01020 - Ribosomal L40e family
PF11976 - Ubiquitin-2 like Rad60 SUMO-like
PF13881 - Ubiquitin-2 like Rad60 SUMO-like
PF14560 - Ubiquitin-like domain

SCOP Domains:
54236 - Ubiquitin-like
54292 - 2Fe-2S ferredoxin-like
57829 - Zn-binding ribosomal proteins

ModBase Predicted Comparative 3D Structure on Q3MIH3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome

Biological Process:
GO:0006412 translation

Cellular Component:
GO:0005654 nucleoplasm
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AF348700 - Homo sapiens ubiquitin A-52 residue ribosomal protein fusion product 1 (UBA52), mRNA, complete cds.
BC101830 - Homo sapiens ubiquitin A-52 residue ribosomal protein fusion product 1, mRNA (cDNA clone MGC:126879 IMAGE:8069336), complete cds.
BC101832 - Homo sapiens ubiquitin A-52 residue ribosomal protein fusion product 1, mRNA (cDNA clone MGC:126881 IMAGE:8069338), complete cds.
BC143668 - Homo sapiens ubiquitin A-52 residue ribosomal protein fusion product 1, mRNA (cDNA clone MGC:177199 IMAGE:9052182), complete cds.
D28425 - Homo sapiens mRNA for ribosomal protein L40, partial cds.
AK314717 - Homo sapiens cDNA, FLJ95576, Homo sapiens ubiquitin A-52 residue ribosomal protein fusionproduct 1 (UBA52), mRNA.
X56998 - Human UbA52 adrenal mRNA for ubiquitin-52 amino acid fusion protein.
X56999 - Human UbA52 placental mRNA for ubiquitin-52 amino acid fusion protein.
AB590876 - Synthetic construct DNA, clone: pFN21AE1618, Homo sapiens UBA52 gene for ubiquitin A-52 residue ribosomal protein fusion product 1, without stop codon, in Flexi system.
KJ892338 - Synthetic construct Homo sapiens clone ccsbBroadEn_01732 UBA52 gene, encodes complete protein.
DQ590888 - Homo sapiens piRNA piR-58000, complete sequence.
Y00361 - Human mRNA fragment for ubiquitin (C-terminus).
DL491652 - Novel nucleic acids.
DL490238 - Novel nucleic acids.
JD474778 - Sequence 455802 from Patent EP1572962.
JD457277 - Sequence 438301 from Patent EP1572962.
AF545864 - Homo sapiens hypothetical protein precursor, mRNA, complete cds.
AK057790 - Homo sapiens cDNA FLJ25061 fis, clone CBL04730.
JD365151 - Sequence 346175 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000442744.1, ENST00000442744.2, ENST00000442744.3, ENST00000442744.4, ENST00000442744.5, ENST00000442744.6, hCG_37048 , NM_003333, Q3MIH3, Q3MIH3_HUMAN, UBA52 , uc320ktb.1, uc320ktb.2
UCSC ID: ENST00000442744.7_4
RefSeq Accession: NM_001033930.3
Protein: Q3MIH3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.