Human Gene UBAP2L (ENST00000428931.6_8) from GENCODE V47lift37

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Description: ubiquitin associated protein 2 like, transcript variant 1 (from RefSeq NM_014847.4)
Gencode Transcript: ENST00000428931.6_8
Gencode Gene: ENSG00000143569.20_17
Transcript (Including UTRs)
Position: hg19 chr1:154,193,431-154,243,323 Size: 49,893 Total Exon Count: 27 Strand: +
Coding Region
Position: hg19 chr1:154,197,600-154,242,771 Size: 45,172 Coding Exon Count: 26

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:154,193,431-154,243,323)			mRNA (may differ from genome)		Protein (1087 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: UBP2L_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-associated protein 2-like; AltName: Full=Protein NICE-4; TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Acetylated. SIMILARITY: Contains 1 UBA domain. SEQUENCE CAUTION: Sequence=CAB65100.2; Type=Frameshift; Positions=1085;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D000082 Acetaminophen D001564 Benzo(a)pyrene D002994 Clofibrate D004958 Estradiol D004997 Ethinyl Estradiol D019833 Genistein D058185 Magnetite Nanoparticles D012643 Selenium D004113 Succimer more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 30.36 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 892.97 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-11.30	61	-0.185	Picture	PostScript	Text
3' UTR	-128.70	552	-0.233	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR022166 - DUF3697_Uba2
IPR009060 - UBA-like
IPR015940 - UBA/transl_elong_EF1B_N_euk

Pfam Domains:
PF12478 - Ubiquitin-associated protein 2

SCOP Domains:
46934 - UBA-like

ModBase Predicted Comparative 3D Structure on Q14157


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0005515 protein binding Biological Process: GO:0007339 binding of sperm to zona pellucida GO:0010628 positive regulation of gene expression GO:0061484 hematopoietic stem cell homeostasis Cellular Component: GO:0005737 cytoplasm GO:0031519 PcG protein complex GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex

Descriptions from all associated GenBank mRNAs


	D63478 - Homo sapiens mRNA for KIAA0144 gene, complete cds. LF206193 - JP 2014500723-A/13696: Polycomb-Associated Non-Coding RNAs. AK302662 - Homo sapiens cDNA FLJ55671 complete cds, highly similar to Ubiquitin-associated protein 2-like. AK303533 - Homo sapiens cDNA FLJ54031 complete cds, highly similar to Ubiquitin-associated protein 2-like. AJ243668 - Homo sapiens partial mRNA for NICE-4 protein, 5' end, clone 1056f5. AK124294 - Homo sapiens cDNA FLJ42300 fis, clone TOVAR2002247, highly similar to Homo sapiens partial partial mRNA for NICE-4 protein. BC003170 - Homo sapiens ubiquitin associated protein 2-like, mRNA (cDNA clone MGC:4404 IMAGE:2906083), complete cds. LF352334 - JP 2014500723-A/159837: Polycomb-Associated Non-Coding RNAs. AB385284 - Synthetic construct DNA, clone: pF1KA0144, Homo sapiens UBAP2L gene for ubiquitin-associated protein 2-like, complete cds, without stop codon, in Flexi system. KJ898112 - Synthetic construct Homo sapiens clone ccsbBroadEn_07506 UBAP2L gene, encodes complete protein. LF352331 - JP 2014500723-A/159834: Polycomb-Associated Non-Coding RNAs. AK302953 - Homo sapiens cDNA FLJ54706 complete cds, highly similar to Ubiquitin-associated protein 2-like. LF352330 - JP 2014500723-A/159833: Polycomb-Associated Non-Coding RNAs. LF352326 - JP 2014500723-A/159829: Polycomb-Associated Non-Coding RNAs. LF352325 - JP 2014500723-A/159828: Polycomb-Associated Non-Coding RNAs. LF352324 - JP 2014500723-A/159827: Polycomb-Associated Non-Coding RNAs. LF352323 - JP 2014500723-A/159826: Polycomb-Associated Non-Coding RNAs. LF352319 - JP 2014500723-A/159822: Polycomb-Associated Non-Coding RNAs. LF352309 - JP 2014500723-A/159812: Polycomb-Associated Non-Coding RNAs. LF352308 - JP 2014500723-A/159811: Polycomb-Associated Non-Coding RNAs. LF352307 - JP 2014500723-A/159810: Polycomb-Associated Non-Coding RNAs. LF352306 - JP 2014500723-A/159809: Polycomb-Associated Non-Coding RNAs. LF352305 - JP 2014500723-A/159808: Polycomb-Associated Non-Coding RNAs. LF352304 - JP 2014500723-A/159807: Polycomb-Associated Non-Coding RNAs. LF352302 - JP 2014500723-A/159805: Polycomb-Associated Non-Coding RNAs. AJ243670 - Homo sapiens partial partial mRNA for NICE-4 protein, clone 3114f17. AJ243669 - Homo sapiens partial mRNA for NICE-4 protein, 3' end, clone 1056f5. LF352301 - JP 2014500723-A/159804: Polycomb-Associated Non-Coding RNAs. LF352299 - JP 2014500723-A/159802: Polycomb-Associated Non-Coding RNAs. LF209462 - JP 2014500723-A/16965: Polycomb-Associated Non-Coding RNAs. LF328736 - JP 2014500723-A/136239: Polycomb-Associated Non-Coding RNAs. LF352294 - JP 2014500723-A/159797: Polycomb-Associated Non-Coding RNAs. LF328738 - JP 2014500723-A/136241: Polycomb-Associated Non-Coding RNAs. LF352293 - JP 2014500723-A/159796: Polycomb-Associated Non-Coding RNAs. LF352290 - JP 2014500723-A/159793: Polycomb-Associated Non-Coding RNAs. LF352289 - JP 2014500723-A/159792: Polycomb-Associated Non-Coding RNAs. MA587911 - JP 2018138019-A/159837: Polycomb-Associated Non-Coding RNAs. MA587908 - JP 2018138019-A/159834: Polycomb-Associated Non-Coding RNAs. MA587907 - JP 2018138019-A/159833: Polycomb-Associated Non-Coding RNAs. MA587903 - JP 2018138019-A/159829: Polycomb-Associated Non-Coding RNAs. MA587902 - JP 2018138019-A/159828: Polycomb-Associated Non-Coding RNAs. MA587901 - JP 2018138019-A/159827: Polycomb-Associated Non-Coding RNAs. MA587900 - JP 2018138019-A/159826: Polycomb-Associated Non-Coding RNAs. MA587896 - JP 2018138019-A/159822: Polycomb-Associated Non-Coding RNAs. MA587886 - JP 2018138019-A/159812: Polycomb-Associated Non-Coding RNAs. MA587885 - JP 2018138019-A/159811: Polycomb-Associated Non-Coding RNAs. MA587884 - JP 2018138019-A/159810: Polycomb-Associated Non-Coding RNAs. MA587883 - JP 2018138019-A/159809: Polycomb-Associated Non-Coding RNAs. MA587882 - JP 2018138019-A/159808: Polycomb-Associated Non-Coding RNAs. MA587881 - JP 2018138019-A/159807: Polycomb-Associated Non-Coding RNAs. MA587879 - JP 2018138019-A/159805: Polycomb-Associated Non-Coding RNAs. MA587878 - JP 2018138019-A/159804: Polycomb-Associated Non-Coding RNAs. MA587876 - JP 2018138019-A/159802: Polycomb-Associated Non-Coding RNAs. MA564313 - JP 2018138019-A/136239: Polycomb-Associated Non-Coding RNAs. MA587871 - JP 2018138019-A/159797: Polycomb-Associated Non-Coding RNAs. MA564315 - JP 2018138019-A/136241: Polycomb-Associated Non-Coding RNAs. MA587870 - JP 2018138019-A/159796: Polycomb-Associated Non-Coding RNAs. MA587867 - JP 2018138019-A/159793: Polycomb-Associated Non-Coding RNAs. MA587866 - JP 2018138019-A/159792: Polycomb-Associated Non-Coding RNAs. MA441770 - JP 2018138019-A/13696: Polycomb-Associated Non-Coding RNAs. MA445039 - JP 2018138019-A/16965: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B4E0U8, ENST00000428931.1, ENST00000428931.2, ENST00000428931.3, ENST00000428931.4, ENST00000428931.5, KIAA0144, NICE4, NM_014847, Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL2, Q9UGL3, Q9UGL4, Q9UGL5, UBAP2L , UBP2L_HUMAN, uc319xwt.1, uc319xwt.2 UCSC ID: ENST00000428931.6_8 RefSeq Accession: NM_014847.4 Protein: Q14157 (aka UBP2L_HUMAN or UP2L_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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