Human Gene UBE2C (ENST00000356455.9_4) from GENCODE V47lift37
  Description: ubiquitin conjugating enzyme E2 C, transcript variant 9 (from RefSeq NR_104037.2)
Gencode Transcript: ENST00000356455.9_4
Gencode Gene: ENSG00000175063.17_7
Transcript (Including UTRs)
   Position: hg19 chr20:44,441,283-44,445,591 Size: 4,309 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr20:44,441,335-44,445,406 Size: 4,072 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:44,441,283-44,445,591)mRNA (may differ from genome)Protein (179 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q5TZN3_HUMAN
DESCRIPTION: SubName: Full=UBE2C protein; SubName: Full=Ubiquitin-conjugating enzyme E2C; SubName: Full=Ubiquitin-conjugating enzyme E2C, isoform CRA_e;
SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.10 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 110.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.0052-0.154 Picture PostScript Text
3' UTR -26.70185-0.144 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000608 - UBQ-conjugat_E2
IPR023313 - UBQ-conjugating_AS
IPR016135 - UBQ-conjugating_enzyme/RWD

Pfam Domains:
PF00179 - Ubiquitin-conjugating enzyme

SCOP Domains:
54495 - UBC-like

ModBase Predicted Comparative 3D Structure on Q5TZN3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity

Cellular Component:
GO:0005829 cytosol
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AK311949 - Homo sapiens cDNA, FLJ92217, highly similar to Homo sapiens ubiquitin-conjugating enzyme E2C (UBE2C), mRNA.
LF383769 - JP 2014500723-A/191272: Polycomb-Associated Non-Coding RNAs.
BC050736 - Homo sapiens ubiquitin-conjugating enzyme E2C, mRNA (cDNA clone MGC:60380 IMAGE:6503915), complete cds.
BC016292 - Homo sapiens ubiquitin-conjugating enzyme E2C, mRNA (cDNA clone MGC:9617 IMAGE:3910286), complete cds.
BC007656 - Homo sapiens ubiquitin-conjugating enzyme E2C, mRNA (cDNA clone MGC:1234 IMAGE:3345575), complete cds.
U73379 - Human cyclin-selective ubiquitin carrier protein mRNA, complete cds.
BC028161 - Homo sapiens ubiquitin-conjugating enzyme E2C, mRNA (cDNA clone IMAGE:5228503).
CR456988 - Homo sapiens full open reading frame cDNA clone RZPDo834D115D for gene UBE2C, ubiquitin-conjugating enzyme E2C; complete cds, incl. stopcodon.
EU831714 - Synthetic construct Homo sapiens clone HAIB:100066743; DKFZo003E0220 ubiquitin-conjugating enzyme E2C protein (UBE2C) gene, encodes complete protein.
BT007300 - Homo sapiens ubiquitin-conjugating enzyme E2C mRNA, complete cds.
BT020165 - Homo sapiens ubiquitin-conjugating enzyme E2C mRNA, complete cds.
BT020166 - Homo sapiens ubiquitin-conjugating enzyme E2C mRNA, complete cds.
EU831629 - Synthetic construct Homo sapiens clone HAIB:100066658; DKFZo007E0219 ubiquitin-conjugating enzyme E2C protein (UBE2C) gene, encodes complete protein.
DQ892416 - Synthetic construct clone IMAGE:100005046; FLH186150.01X; RZPDo839B0671D ubiquitin-conjugating enzyme E2C (UBE2C) gene, encodes complete protein.
DQ895630 - Synthetic construct Homo sapiens clone IMAGE:100010090; FLH186146.01L; RZPDo839B0661D ubiquitin-conjugating enzyme E2C (UBE2C) gene, encodes complete protein.
LF350572 - JP 2014500723-A/158075: Polycomb-Associated Non-Coding RNAs.
LF350575 - JP 2014500723-A/158078: Polycomb-Associated Non-Coding RNAs.
JD200207 - Sequence 181231 from Patent EP1572962.
JD091289 - Sequence 72313 from Patent EP1572962.
MA619346 - JP 2018138019-A/191272: Polycomb-Associated Non-Coding RNAs.
MA586149 - JP 2018138019-A/158075: Polycomb-Associated Non-Coding RNAs.
MA586152 - JP 2018138019-A/158078: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7511 - protein ubiquitination

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000356455.1, ENST00000356455.2, ENST00000356455.3, ENST00000356455.4, ENST00000356455.5, ENST00000356455.6, ENST00000356455.7, ENST00000356455.8, hCG_38372 , NR_104037, Q5TZN3, Q5TZN3_HUMAN, UBE2C , uc317zoh.1, uc317zoh.2
UCSC ID: ENST00000356455.9_4
RefSeq Accession: NM_007019.4
Protein: Q5TZN3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.