ID:UB2E1_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 E1; EC=6.3.2.19; AltName: Full=UbcH6; AltName: Full=Ubiquitin carrier protein E1; AltName: Full=Ubiquitin-protein ligase E1; FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RNF14. INTERACTION: Q8N7H5:PAF1; NbExp=2; IntAct=EBI-348546, EBI-2607770; Q9Y3C5:RNF11; NbExp=2; IntAct=EBI-348546, EBI-396669; Q5VTR2:RNF20; NbExp=2; IntAct=EBI-348546, EBI-2372238; Q8ND25:ZNRF1; NbExp=3; IntAct=EBI-348546, EBI-2129250; SUBCELLULAR LOCATION: Nucleus. PTM: ISGylation suppresses ubiquitin E2 enzyme activity. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51965
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
Reactome (by CSHL, EBI, and GO)
Protein P51965 (Reactome details) participates in the following event(s):
R-HSA-174119 Free APC/C phosphorylated by Plk1 R-HSA-174132 Free APC/C phosphorylated by Cyclin B:Cdc2 R-HSA-174139 Dissociation of phospho-Cdh1 from the APC/C complex R-HSA-141423 Binding of the MCC complex to the APC/C complex R-HSA-174070 Association of Cdh1 with the APC/C R-HSA-174224 Dissociation of Cdc20 from APC/C complex R-HSA-1169402 ISGylation of E2 conjugating enzymes R-HSA-1169406 ISGylation of host proteins R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes R-HSA-174057 Multiubiquitination of APC/C-associated Cdh1 R-HSA-188371 Association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788708 CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788725 Cdh1:APC/C complex binds EHMT1:EHMT2 R-HSA-174171 Association of Cyclin A with the APC/C R-HSA-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 R-HSA-179410 Association of Nek2A with MCC:APC/C R-HSA-174120 Association of Cyclin B:Cdc2 with Cdc20:APC/C complex R-HSA-174121 Association of Securin with Cdc20:APC/C complex R-HSA-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-8939323 RNF181 binds BCL10 and Ubiquitin:E2 R-HSA-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex R-HSA-179417 Multiubiquitination of Nek2A R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex R-HSA-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex R-HSA-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex R-HSA-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex R-HSA-176412 Phosphorylation of the APC/C R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-1169408 ISG15 antiviral mechanism R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-2467813 Separation of Sister Chromatids R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-8852135 Protein ubiquitination R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-2559583 Cellular Senescence R-HSA-453276 Regulation of mitotic cell cycle R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-68882 Mitotic Anaphase R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-913531 Interferon Signaling R-HSA-597592 Post-translational protein modification R-HSA-1280218 Adaptive Immune System R-HSA-2262752 Cellular responses to stress R-HSA-69278 Cell Cycle (Mitotic) R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69620 Cell Cycle Checkpoints R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-392499 Metabolism of proteins R-HSA-168256 Immune System R-HSA-8953897 Cellular responses to external stimuli R-HSA-1640170 Cell Cycle R-HSA-68886 M Phase R-HSA-69239 Synthesis of DNA R-HSA-69242 S Phase R-HSA-69306 DNA Replication
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
