ID:UB2E2_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 E2; EC=6.3.2.19; AltName: Full=UbcH8; AltName: Full=Ubiquitin carrier protein E2; AltName: Full=Ubiquitin-protein ligase E2; FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96LR5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006974 cellular response to DNA damage stimulus GO:0016567 protein ubiquitination GO:0032020 ISG15-protein conjugation GO:0070534 protein K63-linked ubiquitination GO:0070936 protein K48-linked ubiquitination GO:0070979 protein K11-linked ubiquitination GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Descriptions from all associated GenBank mRNAs
AK307075 - Homo sapiens cDNA, FLJ97023. AK057886 - Homo sapiens cDNA FLJ25157 fis, clone CBR08008, highly similar to UBIQUITIN-CONJUGATING ENZYME E2-23 KDA (EC 6.3.2.19). BC022332 - Homo sapiens ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast), mRNA (cDNA clone MGC:22765 IMAGE:4295679), complete cds. KJ892343 - Synthetic construct Homo sapiens clone ccsbBroadEn_01737 UBE2E2 gene, encodes complete protein. JD393432 - Sequence 374456 from Patent EP1572962. JD124028 - Sequence 105052 from Patent EP1572962. JD391958 - Sequence 372982 from Patent EP1572962. JD399259 - Sequence 380283 from Patent EP1572962. JD164381 - Sequence 145405 from Patent EP1572962. JD281691 - Sequence 262715 from Patent EP1572962. JD164044 - Sequence 145068 from Patent EP1572962. JD082125 - Sequence 63149 from Patent EP1572962. JD295301 - Sequence 276325 from Patent EP1572962. JD224091 - Sequence 205115 from Patent EP1572962. JD101272 - Sequence 82296 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
Reactome (by CSHL, EBI, and GO)
Protein Q96LR5 (Reactome details) participates in the following event(s):
R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
