ID:UB2G2_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 G2; EC=6.3.2.19; AltName: Full=Ubiquitin carrier protein G2; AltName: Full=Ubiquitin-protein ligase G2; FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD). CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P60604
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0016567 protein ubiquitination GO:0018279 protein N-linked glycosylation via asparagine GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0035458 cellular response to interferon-beta GO:0044257 cellular protein catabolic process GO:0070936 protein K48-linked ubiquitination GO:1904153 negative regulation of retrograde protein transport, ER to cytosol
AF032456 - Homo sapiens ubiquitin conjugating enzyme G2 (UBE2G2) mRNA, complete cds. BC017241 - Homo sapiens ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast), mRNA (cDNA clone IMAGE:4647334), partial cds. AL834129 - Homo sapiens mRNA; cDNA DKFZp586L2318 (from clone DKFZp586L2318). BC008351 - Homo sapiens ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast), mRNA (cDNA clone MGC:15927 IMAGE:3536171), complete cds. BC001738 - Homo sapiens ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast), mRNA (cDNA clone MGC:1589 IMAGE:3536853), complete cds. AK122700 - Homo sapiens cDNA FLJ16170 fis, clone BRHIP2003062, moderately similar to Ubiquitin-conjugating enzyme E2 G2 (EC 6.3.2.19). JD079571 - Sequence 60595 from Patent EP1572962. JD197091 - Sequence 178115 from Patent EP1572962. JD136185 - Sequence 117209 from Patent EP1572962. JD523319 - Sequence 504343 from Patent EP1572962. JD101836 - Sequence 82860 from Patent EP1572962. JD047505 - Sequence 28529 from Patent EP1572962. JD246796 - Sequence 227820 from Patent EP1572962. JD273249 - Sequence 254273 from Patent EP1572962. JD231359 - Sequence 212383 from Patent EP1572962. JD315667 - Sequence 296691 from Patent EP1572962. JD450456 - Sequence 431480 from Patent EP1572962. JD451108 - Sequence 432132 from Patent EP1572962. JD108629 - Sequence 89653 from Patent EP1572962. JD549953 - Sequence 530977 from Patent EP1572962. JD402068 - Sequence 383092 from Patent EP1572962. JD278562 - Sequence 259586 from Patent EP1572962. JD426024 - Sequence 407048 from Patent EP1572962. JD558103 - Sequence 539127 from Patent EP1572962. JD121343 - Sequence 102367 from Patent EP1572962. JD552967 - Sequence 533991 from Patent EP1572962. JD553429 - Sequence 534453 from Patent EP1572962. BC011569 - Homo sapiens ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast), mRNA (cDNA clone MGC:20221 IMAGE:4548763), complete cds. AK075143 - Homo sapiens cDNA FLJ90662 fis, clone PLACE1005005, highly similar to Homo sapiens ubiquitin conjugating enzyme G2 (UBE2G2) mRNA. JD311237 - Sequence 292261 from Patent EP1572962. JD170880 - Sequence 151904 from Patent EP1572962. JD530582 - Sequence 511606 from Patent EP1572962. JD446266 - Sequence 427290 from Patent EP1572962. JD395409 - Sequence 376433 from Patent EP1572962. JD125597 - Sequence 106621 from Patent EP1572962. JD025138 - Sequence 6162 from Patent EP1572962. JD159700 - Sequence 140724 from Patent EP1572962. JD376347 - Sequence 357371 from Patent EP1572962. JD486469 - Sequence 467493 from Patent EP1572962. JD075003 - Sequence 56027 from Patent EP1572962. JD075002 - Sequence 56026 from Patent EP1572962. JD371721 - Sequence 352745 from Patent EP1572962. JD257749 - Sequence 238773 from Patent EP1572962. JD289405 - Sequence 270429 from Patent EP1572962. JD500611 - Sequence 481635 from Patent EP1572962. JD489608 - Sequence 470632 from Patent EP1572962. JD279608 - Sequence 260632 from Patent EP1572962. JD538384 - Sequence 519408 from Patent EP1572962. JD384650 - Sequence 365674 from Patent EP1572962. JD155368 - Sequence 136392 from Patent EP1572962. JD297341 - Sequence 278365 from Patent EP1572962. AK290629 - Homo sapiens cDNA FLJ76118 complete cds, highly similar to Homo sapiens ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) (UBE2G2), transcript variant 1, mRNA. JD180576 - Sequence 161600 from Patent EP1572962. JD451912 - Sequence 432936 from Patent EP1572962. JD393595 - Sequence 374619 from Patent EP1572962. JD127156 - Sequence 108180 from Patent EP1572962. JD136814 - Sequence 117838 from Patent EP1572962. JD348141 - Sequence 329165 from Patent EP1572962. JD510136 - Sequence 491160 from Patent EP1572962. JD163001 - Sequence 144025 from Patent EP1572962. JD299380 - Sequence 280404 from Patent EP1572962. JD053418 - Sequence 34442 from Patent EP1572962. JD187534 - Sequence 168558 from Patent EP1572962. JD259645 - Sequence 240669 from Patent EP1572962. JD170910 - Sequence 151934 from Patent EP1572962. JF432837 - Synthetic construct Homo sapiens clone IMAGE:100074157 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) (UBE2G2) gene, encodes complete protein. KJ892345 - Synthetic construct Homo sapiens clone ccsbBroadEn_01739 UBE2G2 gene, encodes complete protein. BT006914 - Homo sapiens ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) mRNA, complete cds. AB590900 - Synthetic construct DNA, clone: pFN21AE1128, Homo sapiens UBE2G2 gene for ubiquitin-conjugating enzyme E2G 2, without stop codon, in Flexi system. BC054341 - Homo sapiens ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast), mRNA (cDNA clone IMAGE:6504265), partial cds. AL355686 - Homo sapiens EST from clone 37208, full insert.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
BioCarta from NCI Cancer Genome Anatomy Project h_parkinPathway - Role of Parkin in the Ubiquitin-Proteasomal Pathway
Reactome (by CSHL, EBI, and GO)
Protein P60604 (Reactome details) participates in the following event(s):
R-HSA-8852127 UBA6 conjugates ubiquitin to cytosolic E2 enzymes R-HSA-8852129 UBA1 conjugates ubiquitin to cytosolic E2 enzymes R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-8852135 Protein ubiquitination R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-597592 Post-translational protein modification R-HSA-1280218 Adaptive Immune System R-HSA-392499 Metabolism of proteins R-HSA-168256 Immune System