ID:UBE2S_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 S; EC=6.3.2.19; AltName: Full=E2-EPF; AltName: Full=Ubiquitin carrier protein S; AltName: Full=Ubiquitin-conjugating enzyme E2-24 kDa; AltName: Full=Ubiquitin-conjugating enzyme E2-EPF5; AltName: Full=Ubiquitin-protein ligase S; FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL. PTM: Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16763
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006464 cellular protein modification process GO:0007049 cell cycle GO:0010458 exit from mitosis GO:0010994 free ubiquitin chain polymerization GO:0016567 protein ubiquitination GO:0031145 anaphase-promoting complex-dependent catabolic process GO:0035519 protein K29-linked ubiquitination GO:0044314 protein K27-linked ubiquitination GO:0051301 cell division GO:0070534 protein K63-linked ubiquitination GO:0070979 protein K11-linked ubiquitination GO:0085020 protein K6-linked ubiquitination GO:1904668 positive regulation of ubiquitin protein ligase activity
LP896144 - Sequence 1008 from Patent EP3253886. M91670 - Human ubiquitin carrier protein (E2-EPF) mRNA, complete cds. AB062397 - Homo sapiens OK/SW-cl.73 mRNA for ubiquitin carrier protein, complete cds. BC004236 - Homo sapiens ubiquitin-conjugating enzyme E2S, mRNA (cDNA clone MGC:801 IMAGE:2988449), complete cds. BC007554 - Homo sapiens ubiquitin-conjugating enzyme E2S, mRNA (cDNA clone MGC:15477 IMAGE:2967547), complete cds. BC065364 - Homo sapiens ubiquitin-conjugating enzyme E2S, mRNA (cDNA clone MGC:71276 IMAGE:5434942), complete cds. JD466978 - Sequence 448002 from Patent EP1572962. KJ898690 - Synthetic construct Homo sapiens clone ccsbBroadEn_08084 UBE2S gene, encodes complete protein. KJ898691 - Synthetic construct Homo sapiens clone ccsbBroadEn_08085 UBE2S gene, encodes complete protein. CU688218 - Synthetic construct Homo sapiens gateway clone IMAGE:100021039 5' read UBE2S mRNA. CU675699 - Synthetic construct Homo sapiens gateway clone IMAGE:100023219 5' read UBE2S mRNA. JD021187 - Sequence 2211 from Patent EP1572962. JD031411 - Sequence 12435 from Patent EP1572962. JD078831 - Sequence 59855 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
Reactome (by CSHL, EBI, and GO)
Protein Q16763 (Reactome details) participates in the following event(s):
R-HSA-8852127 UBA6 conjugates ubiquitin to cytosolic E2 enzymes R-HSA-8852129 UBA1 conjugates ubiquitin to cytosolic E2 enzymes R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-8852135 Protein ubiquitination R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-597592 Post-translational protein modification R-HSA-1280218 Adaptive Immune System R-HSA-392499 Metabolism of proteins R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
