ID:UB2V2_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 variant 2; AltName: Full=DDVit 1; AltName: Full=Enterocyte differentiation-associated factor 1; Short=EDAF-1; AltName: Full=Enterocyte differentiation-promoting factor 1; Short=EDPF-1; AltName: Full=MMS2 homolog; AltName: Full=Vitamin D3-inducible protein; FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. SUBUNIT: Heterodimer with UBE2N. Binds CHFR. INTERACTION: Q94A97:UBC35 (xeno); NbExp=3; IntAct=EBI-714329, EBI-994120; P61088:UBE2N; NbExp=3; IntAct=EBI-714329, EBI-1052908; TISSUE SPECIFICITY: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. INDUCTION: Up-regulated in cultured fresh blood cells upon treatment with vitamin D3. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15819
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0031625 ubiquitin protein ligase binding GO:0061630 ubiquitin protein ligase activity GO:0061631 ubiquitin conjugating enzyme activity
Biological Process: GO:0000209 protein polyubiquitination GO:0000729 DNA double-strand break processing GO:0006282 regulation of DNA repair GO:0006301 postreplication repair GO:0006303 double-strand break repair via nonhomologous end joining GO:0008283 cell proliferation GO:0010976 positive regulation of neuron projection development GO:0016567 protein ubiquitination GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0042275 error-free postreplication DNA repair GO:0043524 negative regulation of neuron apoptotic process GO:0045739 positive regulation of DNA repair GO:0051965 positive regulation of synapse assembly GO:0070534 protein K63-linked ubiquitination
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
Reactome (by CSHL, EBI, and GO)
Protein Q15819 (Reactome details) participates in the following event(s):
R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-5682629 HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 R-HSA-5684071 RNF4 ubiquitinates MDC1 R-HSA-5693599 Association of Ku heterodimer with ends of DNA double-strand break R-HSA-6790487 RNF111 ubiquitinates SUMOylated XPC R-HSA-8943007 SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N R-HSA-8943041 HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-5682863 RNF168 binds DNA DSBs R-HSA-5683077 RNF8 and RNF168 ubiquitinate KDM4A,B R-HSA-5682858 RNF8 and RNF168 ubiquitinate H2AFX R-HSA-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs R-HSA-5683384 UIMC1 and FAM175A bind DNA DSBs R-HSA-5683405 PPP5C dephosphorylates TP53BP1 R-HSA-5683425 ATM phosphorylates TP53BP1 at DNA DSBs R-HSA-5693551 Phosphorylation of BRCA1-A complex at multiple sites by ATM R-HSA-5683385 Formation of BRCA1-A complex at DNA DSBs R-HSA-5683735 CHEK2 is recruited to DNA DSBs R-HSA-5683801 CHEK2 phosphorylates BRCA1 R-HSA-69891 Phosphorylation and activation of CHEK2 by ATM R-HSA-5684052 PIAS4 SUMOylates MDC1 R-HSA-5686685 RIF1 and PAX1IP bind TP53BP1 at DNA DSBs R-HSA-5686900 TP53BP1 recruits DCLRE1C to ATM R-HSA-5686704 Activated ATM phosphorylates DCLRE1C R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693607 Processing of DNA double-strand break ends R-HSA-5693571 Nonhomologous End-Joining (NHEJ) R-HSA-5696395 Formation of Incision Complex in GG-NER R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-5693606 DNA Double Strand Break Response R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5693532 DNA Double-Strand Break Repair R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-8852135 Protein ubiquitination R-HSA-1280218 Adaptive Immune System R-HSA-5693538 Homology Directed Repair R-HSA-73894 DNA Repair R-HSA-5696398 Nucleotide Excision Repair R-HSA-597592 Post-translational protein modification R-HSA-168256 Immune System R-HSA-392499 Metabolism of proteins R-HSA-69473 G2/M DNA damage checkpoint R-HSA-69481 G2/M Checkpoints R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle
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Common Gene Haplotype Alleles 
