Human Gene UBL3 (ENST00000380680.5_7) from GENCODE V47lift37

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Description: ubiquitin like 3 (from RefSeq NM_007106.4)
Gencode Transcript: ENST00000380680.5_7
Gencode Gene: ENSG00000122042.10_9
Transcript (Including UTRs)
Position: hg19 chr13:30,338,508-30,424,754 Size: 86,247 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr13:30,341,392-30,423,675 Size: 82,284 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr13:30,338,508-30,424,754)			mRNA (may differ from genome)		Protein (117 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: UBL3_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-like protein 3; AltName: Full=Membrane-anchored ubiquitin-fold protein; Short=HsMUB; Short=MUB; AltName: Full=Protein HCG-1; Flags: Precursor; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor (By similarity). TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 1 ubiquitin-like domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D013749 Tetrachlorodibenzodioxin C006780 bisphenol A C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester D001564 Benzo(a)pyrene D002995 Clofibric Acid D019327 Copper Sulfate D003561 Cytarabine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 40.47 RPKM in Brain - Spinal cord (cervical c-1) Total median expression: 939.55 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-488.10	1079	-0.452	Picture	PostScript	Text
3' UTR	-616.40	2884	-0.214	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR017000 - M-anchored_Ub-fold_HCG-1
IPR019955 - Ubiquitin_supergroup

Pfam Domains:
PF13881 - Ubiquitin-2 like Rad60 SUMO-like

SCOP Domains:
54236 - Ubiquitin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2GOW - NMR MuPIT

ModBase Predicted Comparative 3D Structure on O95164


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0005622 intracellular GO:0005886 plasma membrane GO:0016020 membrane GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BC059385 - Homo sapiens ubiquitin-like 3, mRNA (cDNA clone MGC:71681 IMAGE:5287541), complete cds. AL080177 - Homo sapiens mRNA; cDNA DKFZp434K151 (from clone DKFZp434K151). BC044582 - Homo sapiens ubiquitin-like 3, mRNA (cDNA clone MGC:57181 IMAGE:5262176), complete cds. AF044221 - Homo sapiens HCG-1 protein (HCG-1) mRNA, complete cds. AK056580 - Homo sapiens cDNA FLJ32018 fis, clone NTONG1000087, highly similar to Ubiquitin-like protein 3. AK307361 - Homo sapiens cDNA, FLJ97309. AK309253 - Homo sapiens cDNA, FLJ99294. CR533458 - Homo sapiens full open reading frame cDNA clone RZPDo834E1116D for gene UBL3, ubiquitin-like 3; complete cds, incl. stopcodon. AK311846 - Homo sapiens cDNA, FLJ92110, Homo sapiens ubiquitin-like 3 (UBL3), mRNA. KJ891838 - Synthetic construct Homo sapiens clone ccsbBroadEn_01232 UBL3 gene, encodes complete protein. AM393248 - Synthetic construct Homo sapiens clone IMAGE:100001890 for hypothetical protein (UBL3 gene). AM393364 - Synthetic construct Homo sapiens clone IMAGE:100001888 for hypothetical protein (UBL3 gene). JD499294 - Sequence 480318 from Patent EP1572962. JD240318 - Sequence 221342 from Patent EP1572962. JD302600 - Sequence 283624 from Patent EP1572962. JD237569 - Sequence 218593 from Patent EP1572962. JD173788 - Sequence 154812 from Patent EP1572962. JD265119 - Sequence 246143 from Patent EP1572962. JD510111 - Sequence 491135 from Patent EP1572962. JD552896 - Sequence 533920 from Patent EP1572962. JD050030 - Sequence 31054 from Patent EP1572962. JD269235 - Sequence 250259 from Patent EP1572962. JD556940 - Sequence 537964 from Patent EP1572962. JD114029 - Sequence 95053 from Patent EP1572962. JD063299 - Sequence 44323 from Patent EP1572962. JD284562 - Sequence 265586 from Patent EP1572962. JD113217 - Sequence 94241 from Patent EP1572962. JD377228 - Sequence 358252 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B2R4J1, ENST00000380680.1, ENST00000380680.2, ENST00000380680.3, ENST00000380680.4, NM_007106, O95164, PNSC1, Q5RL72, Q5VZS0, Q6FIG8, Q96SG7, UBL3_HUMAN, uc318ptp.1, uc318ptp.2 UCSC ID: ENST00000380680.5_7 RefSeq Accession: NM_007106.4 Protein: O95164 (aka UBL3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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