Human Gene UBL4A (ENST00000369660.9_7) from GENCODE V47lift37
  Description: ubiquitin like 4A (from RefSeq NM_014235.5)
Gencode Transcript: ENST00000369660.9_7
Gencode Gene: ENSG00000102178.13_10
Transcript (Including UTRs)
   Position: hg19 chrX:153,712,056-153,714,954 Size: 2,899 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chrX:153,713,878-153,714,923 Size: 1,046 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:153,712,056-153,714,954)mRNA (may differ from genome)Protein (157 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UBL4A_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin-like protein 4A; AltName: Full=Ubiquitin-like protein GDX;
FUNCTION: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.
SUBUNIT: Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET3/TRC35.
INTERACTION: P12504:vif (xeno); NbExp=2; IntAct=EBI-356983, EBI-779991;
SUBCELLULAR LOCATION: Cytoplasm, cytosol.
SIMILARITY: Contains 1 ubiquitin-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: UBL4A
Diseases sorted by gene-association score: glaucoma 1, open angle, e (2), suppression amblyopia (2), optic disk drusen (2), glaucoma, normal tension (1), juvenile glaucoma (1), neuroretinitis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.07 RPKM in Brain - Cortex
Total median expression: 828.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.7031-0.281 Picture PostScript Text
3' UTR -710.301822-0.390 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000626 - Ubiquitin
IPR019954 - Ubiquitin_CS
IPR019956 - Ubiquitin_subgr
IPR019955 - Ubiquitin_supergroup

Pfam Domains:
PF00240 - Ubiquitin family
PF11976 - Ubiquitin-2 like Rad60 SUMO-like
PF17840 - Tethering Ubl4a to BAGS domain

SCOP Domains:
54236 - Ubiquitin-like
54277 - CAD & PB1 domains

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2DZI - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P11441
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019787 ubiquitin-like protein transferase activity
GO:0051087 chaperone binding

Biological Process:
GO:0006464 cellular protein modification process
GO:0071816 tail-anchored membrane protein insertion into ER membrane

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0071818 BAT3 complex


-  Descriptions from all associated GenBank mRNAs
  BC043346 - Homo sapiens ubiquitin-like 4A, mRNA (cDNA clone MGC:49894 IMAGE:6058941), complete cds.
AK000405 - Homo sapiens cDNA FLJ20398 fis, clone KAT00580, highly similar to M35604 Human glucose-6-phosphate dehydrogenase.
LF380900 - JP 2014500723-A/188403: Polycomb-Associated Non-Coding RNAs.
BC053589 - Homo sapiens ubiquitin-like 4A, mRNA (cDNA clone MGC:61452 IMAGE:5246329), complete cds.
M35604 - Homo sapiens glucose-6-phosphate dehydrogenase (G6PD) mRNA, partial 3'UTR.
BC020254 - Homo sapiens ubiquitin-like 4A, mRNA (cDNA clone IMAGE:4861293).
AK293227 - Homo sapiens cDNA FLJ59175 complete cds, weakly similar to Ubiquitin-like protein 4A.
HQ448528 - Synthetic construct Homo sapiens clone IMAGE:100071963; CCSB011426_03 ubiquitin-like 4A (UBL4A) gene, encodes complete protein.
KJ892484 - Synthetic construct Homo sapiens clone ccsbBroadEn_01878 UBL4A gene, encodes complete protein.
LF380902 - JP 2014500723-A/188405: Polycomb-Associated Non-Coding RNAs.
LF380903 - JP 2014500723-A/188406: Polycomb-Associated Non-Coding RNAs.
MA616477 - JP 2018138019-A/188403: Polycomb-Associated Non-Coding RNAs.
MA616479 - JP 2018138019-A/188405: Polycomb-Associated Non-Coding RNAs.
MA616480 - JP 2018138019-A/188406: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: DXS254E, ENST00000369660.1, ENST00000369660.2, ENST00000369660.3, ENST00000369660.4, ENST00000369660.5, ENST00000369660.6, ENST00000369660.7, ENST00000369660.8, GDX, NM_014235, P11441, Q5HY80, UBL4, UBL4A , UBL4A_HUMAN, uc318htd.1, uc318htd.2
UCSC ID: ENST00000369660.9_7
RefSeq Accession: NM_014235.5
Protein: P11441 (aka UBL4A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.