Human Gene UBL7 (ENST00000395081.7_7) from GENCODE V47lift37
  Description: ubiquitin like 7, transcript variant 1 (from RefSeq NM_032907.5)
Gencode Transcript: ENST00000395081.7_7
Gencode Gene: ENSG00000138629.16_12
Transcript (Including UTRs)
   Position: hg19 chr15:74,738,318-74,753,501 Size: 15,184 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr15:74,738,431-74,751,208 Size: 12,778 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:74,738,318-74,753,501)mRNA (may differ from genome)Protein (380 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UBL7_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin-like protein 7; AltName: Full=Bone marrow stromal cell ubiquitin-like protein; Short=BMSC-UbP; AltName: Full=Ubiquitin-like protein SB132;
SUBUNIT: Binds ubiquitin.
TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart, skeletal muscle, testis, thyroid and adrenal gland.
INDUCTION: Down-regulated by phorbol myristate acetate (PMA) in bone marrow stroma cells.
SIMILARITY: Contains 1 UBA domain.
SIMILARITY: Contains 1 ubiquitin-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.55 RPKM in Testis
Total median expression: 1127.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.10153-0.380 Picture PostScript Text
3' UTR -30.70113-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009060 - UBA-like
IPR000449 - UBA/transl_elong_EF1B_N
IPR015940 - UBA/transl_elong_EF1B_N_euk
IPR015496 - Ubiquilin
IPR000626 - Ubiquitin
IPR019955 - Ubiquitin_supergroup

Pfam Domains:
PF00240 - Ubiquitin family
PF14560 - Ubiquitin-like domain

SCOP Domains:
46934 - UBA-like
54236 - Ubiquitin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2CWB - NMR MuPIT 2DEN - NMR


ModBase Predicted Comparative 3D Structure on Q96S82
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  LF208521 - JP 2014500723-A/16024: Polycomb-Associated Non-Coding RNAs.
BC007913 - Homo sapiens ubiquitin-like 7 (bone marrow stromal cell-derived), mRNA (cDNA clone MGC:14421 IMAGE:4302762), complete cds.
BC030055 - Homo sapiens ubiquitin-like 7 (bone marrow stromal cell-derived), mRNA (cDNA clone MGC:23165 IMAGE:4873512), complete cds.
BC033919 - Homo sapiens ubiquitin-like 7 (bone marrow stromal cell-derived), mRNA (cDNA clone MGC:23135 IMAGE:4904699), complete cds.
AY037166 - Homo sapiens ubiquitin-like protein SB132 mRNA, complete cds.
JD377218 - Sequence 358242 from Patent EP1572962.
HQ448232 - Synthetic construct Homo sapiens clone IMAGE:100071633; CCSB005194_03 ubiquitin-like 7 (bone marrow stromal cell-derived) (UBL7) gene, encodes complete protein.
KJ895070 - Synthetic construct Homo sapiens clone ccsbBroadEn_04464 UBL7 gene, encodes complete protein.
CU675859 - Synthetic construct Homo sapiens gateway clone IMAGE:100017137 5' read UBL7 mRNA.
LF377245 - JP 2014500723-A/184748: Polycomb-Associated Non-Coding RNAs.
LF377240 - JP 2014500723-A/184743: Polycomb-Associated Non-Coding RNAs.
JD038050 - Sequence 19074 from Patent EP1572962.
MA444098 - JP 2018138019-A/16024: Polycomb-Associated Non-Coding RNAs.
MA612822 - JP 2018138019-A/184748: Polycomb-Associated Non-Coding RNAs.
MA612817 - JP 2018138019-A/184743: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BMSCUBP, D3DW57, ENST00000395081.1, ENST00000395081.2, ENST00000395081.3, ENST00000395081.4, ENST00000395081.5, ENST00000395081.6, NM_032907, Q96I03, Q96S82, SB132, UBL7_HUMAN, uc318xdj.1, uc318xdj.2
UCSC ID: ENST00000395081.7_7
RefSeq Accession: NM_032907.5
Protein: Q96S82 (aka UBL7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.