ID:UBQL2_HUMAN DESCRIPTION: RecName: Full=Ubiquilin-2; AltName: Full=Chap1; AltName: Full=DSK2 homolog; AltName: Full=Protein linking IAP with cytoskeleton 2; Short=PLIC-2; Short=hPLIC-2; AltName: Full=Ubiquitin-like product Chap1/Dsk2; FUNCTION: Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation. SUBUNIT: Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit. INTERACTION: P54725:RAD23A; NbExp=3; IntAct=EBI-947187, EBI-746453; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Where it colocalizes with the proteasome. Associated with fibers in mitotic cells. INDUCTION: Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low. DISEASE: Defects in UBQLN2 are the cause of amyotrophic lateral sclerosis type 15 with or without frontotemporal dementia (ALS15) [MIM:300857]. A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia. SIMILARITY: Contains 1 UBA domain. SIMILARITY: Contains 1 ubiquitin-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UHD9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006914 autophagy GO:0016241 regulation of macroautophagy GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:1900186 negative regulation of clathrin-dependent endocytosis GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process GO:1904021 negative regulation of G-protein coupled receptor internalization GO:2000785 regulation of autophagosome assembly
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
