ID:UBR2_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase UBR2; EC=6.3.2.-; AltName: Full=N-recognin-2; AltName: Full=Ubiquitin-protein ligase E3-alpha-2; AltName: Full=Ubiquitin-protein ligase E3-alpha-II; FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with UBE2B; promotes the UBE2B-H2A interaction and the ubiquitination of histone H2A by UBE2B and UBR2 (By similarity). Interacts with RECQL4. INTERACTION: P12504:vif (xeno); NbExp=3; IntAct=EBI-1237260, EBI-779991; SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Associated with chromatin during meiosis. TISSUE SPECIFICITY: Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). DEVELOPMENTAL STAGE: Expressed in fetal pancreas. DOMAIN: The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif. SIMILARITY: Belongs to the UBR1 family. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 UBR-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IWV8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006342 chromatin silencing GO:0006511 ubiquitin-dependent protein catabolic process GO:0007131 reciprocal meiotic recombination GO:0007140 male meiosis GO:0007141 male meiosis I GO:0007283 spermatogenesis GO:0010529 negative regulation of transposition GO:0016567 protein ubiquitination GO:0030163 protein catabolic process GO:0032007 negative regulation of TOR signaling GO:0033522 histone H2A ubiquitination GO:0071233 cellular response to leucine GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway
BC156045 - Synthetic construct Homo sapiens clone IMAGE:100062317, MGC:190459 ubiquitin protein ligase E3 component n-recognin 2 (UBR2) mRNA, encodes complete protein. AY061884 - Homo sapiens ubiquitin ligase E3 alpha-II mRNA, complete cds. BX647467 - Homo sapiens mRNA; cDNA DKFZp686C08114 (from clone DKFZp686C08114). AK304070 - Homo sapiens cDNA FLJ55442 complete cds, highly similar to Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-). AK310532 - Homo sapiens cDNA, FLJ17574. AK125795 - Homo sapiens cDNA FLJ43807 fis, clone TESTI4001106, weakly similar to Mus musculus ubiquitin protein ligase E3 component n-recognin 1. BC024217 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 2, mRNA (cDNA clone IMAGE:3837513), complete cds. BC064512 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 2, mRNA (cDNA clone IMAGE:3836601), complete cds. CU687884 - Synthetic construct Homo sapiens gateway clone IMAGE:100022479 5' read UBR2 mRNA. KJ898471 - Synthetic construct Homo sapiens clone ccsbBroadEn_07865 UBR2 gene, encodes complete protein. BC080623 - Homo sapiens cDNA clone IMAGE:6302734. AB002347 - Homo sapiens mRNA for KIAA0349 gene, partial cds. AK026998 - Homo sapiens cDNA: FLJ23345 fis, clone HEP13679. AK093676 - Homo sapiens cDNA FLJ36357 fis, clone THYMU2007493. AK026948 - Homo sapiens cDNA: FLJ23295 fis, clone HEP10637. AK127310 - Homo sapiens cDNA FLJ45378 fis, clone BRHIP3020046, highly similar to Ubiquitin-protein ligase E3 componentN-recognin-2 (EC 6.-.-.-). HM370397 - Homo sapiens ubiquitin protein ligase E3 component n-recognin 2-like (UBR2) mRNA, partial sequence, alternatively spliced. AK090874 - Homo sapiens cDNA FLJ33555 fis, clone BRAMY2009349, moderately similar to Mus musculus ubiquitin-protein ligase E3-alpha (Ubr1) mRNA. AX746658 - Sequence 183 from Patent EP1308459. JD042793 - Sequence 23817 from Patent EP1572962. JD062859 - Sequence 43883 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8IWV8 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
