ID:UCP2_HUMAN DESCRIPTION: RecName: Full=Mitochondrial uncoupling protein 2; Short=UCP 2; AltName: Full=Solute carrier family 25 member 8; AltName: Full=UCPH; FUNCTION: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. SUBUNIT: Acts as a dimer forming a proton channel (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle. POLYMORPHISM: Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIM:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ucp2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55851
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0017077 oxidative phosphorylation uncoupler activity
Biological Process: GO:0000303 response to superoxide GO:0001666 response to hypoxia GO:0006839 mitochondrial transport GO:0007565 female pregnancy GO:0007568 aging GO:0009409 response to cold GO:0009749 response to glucose GO:0010942 positive regulation of cell death GO:0032869 cellular response to insulin stimulus GO:0032870 cellular response to hormone stimulus GO:0034198 cellular response to amino acid starvation GO:0043066 negative regulation of apoptotic process GO:0051881 regulation of mitochondrial membrane potential GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0070542 response to fatty acid GO:0071333 cellular response to glucose stimulus GO:0097421 liver regeneration GO:1902600 hydrogen ion transmembrane transport GO:1990542 mitochondrial transmembrane transport GO:1990845 adaptive thermogenesis
LF207790 - JP 2014500723-A/15293: Polycomb-Associated Non-Coding RNAs. AK025742 - Homo sapiens cDNA: FLJ22089 fis, clone HEP16080, highly similar to HSU94592 Human uncoupling protein homolog (UCPH) mRNA. U94592 - Homo sapiens uncoupling protein homolog (UCPH) mRNA, complete cds. BC011737 - Homo sapiens uncoupling protein 2 (mitochondrial, proton carrier), mRNA (cDNA clone MGC:19567 IMAGE:4335185), complete cds. JD381872 - Sequence 362896 from Patent EP1572962. AK222557 - Homo sapiens mRNA for uncoupling protein 2 variant, clone: adSU01813. AK222540 - Homo sapiens mRNA for uncoupling protein 2 variant, clone: adSE01386. LF369211 - JP 2014500723-A/176714: Polycomb-Associated Non-Coding RNAs. JD297628 - Sequence 278652 from Patent EP1572962. JD164746 - Sequence 145770 from Patent EP1572962. JD153927 - Sequence 134951 from Patent EP1572962. LF369210 - JP 2014500723-A/176713: Polycomb-Associated Non-Coding RNAs. U82819 - Homo sapiens UCP2 mRNA, complete cds. JD258722 - Sequence 239746 from Patent EP1572962. JD424076 - Sequence 405100 from Patent EP1572962. JD477140 - Sequence 458164 from Patent EP1572962. JD402792 - Sequence 383816 from Patent EP1572962. JD341639 - Sequence 322663 from Patent EP1572962. JD326541 - Sequence 307565 from Patent EP1572962. CU680034 - Synthetic construct Homo sapiens gateway clone IMAGE:100020684 5' read UCP2 mRNA. U76367 - Human uncoupling protein-2 (UCP2) mRNA, nuclear gene encoding mitochondrial protein, complete cds. KJ892353 - Synthetic construct Homo sapiens clone ccsbBroadEn_01747 UCP2 gene, encodes complete protein. KR710420 - Synthetic construct Homo sapiens clone CCSBHm_00012303 UCP2 (UCP2) mRNA, encodes complete protein. KR710421 - Synthetic construct Homo sapiens clone CCSBHm_00012304 UCP2 (UCP2) mRNA, encodes complete protein. KR710422 - Synthetic construct Homo sapiens clone CCSBHm_00012305 UCP2 (UCP2) mRNA, encodes complete protein. KR710423 - Synthetic construct Homo sapiens clone CCSBHm_00012307 UCP2 (UCP2) mRNA, encodes complete protein. DQ893298 - Synthetic construct clone IMAGE:100005928; FLH199500.01X; RZPDo839E0882D uncoupling protein 2 (mitochondrial, proton carrier) (UCP2) gene, encodes complete protein. DQ896736 - Synthetic construct Homo sapiens clone IMAGE:100011196; FLH199406.01L; RZPDo839E0881D uncoupling protein 2 (mitochondrial, proton carrier) (UCP2) gene, encodes complete protein. AB590212 - Synthetic construct DNA, clone: pFN21AE1315, Homo sapiens UCP2 gene for uncoupling protein 2, without stop codon, in Flexi system. LF369209 - JP 2014500723-A/176712: Polycomb-Associated Non-Coding RNAs. LF369207 - JP 2014500723-A/176710: Polycomb-Associated Non-Coding RNAs. JD290026 - Sequence 271050 from Patent EP1572962. JD228386 - Sequence 209410 from Patent EP1572962. JD161811 - Sequence 142835 from Patent EP1572962. JD391149 - Sequence 372173 from Patent EP1572962. JD268211 - Sequence 249235 from Patent EP1572962. JD394816 - Sequence 375840 from Patent EP1572962. JD472028 - Sequence 453052 from Patent EP1572962. JD349075 - Sequence 330099 from Patent EP1572962. JD209691 - Sequence 190715 from Patent EP1572962. JD396947 - Sequence 377971 from Patent EP1572962. MA604788 - JP 2018138019-A/176714: Polycomb-Associated Non-Coding RNAs. MA604787 - JP 2018138019-A/176713: Polycomb-Associated Non-Coding RNAs. MA604786 - JP 2018138019-A/176712: Polycomb-Associated Non-Coding RNAs. MA604784 - JP 2018138019-A/176710: Polycomb-Associated Non-Coding RNAs. MA443367 - JP 2018138019-A/15293: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P55851 (Reactome details) participates in the following event(s):
R-HSA-166220 FA anion diffuses laterally to UCP R-HSA-166387 The FA anion diffuses away laterally from UCP R-HSA-166214 FA anion flip-flops to the opposite surface R-HSA-170026 Protons are translocated from the intermembrane space to the matrix R-HSA-167826 The fatty acid cycling model R-HSA-166187 Mitochondrial Uncoupling Proteins R-HSA-167827 The proton buffering model R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
