ID:URM1_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-related modifier 1 homolog; FUNCTION: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo. PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine- tRNA biosynthesis. SUBUNIT: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. SUBCELLULAR LOCATION: Cytoplasm. PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3. SIMILARITY: Belongs to the URM1 family. CAUTION: It has not been determined whether conjugation with target proteins involves the formation of thioester-type bonds or isopeptide bonds. The formation of a free thiocarboxylate group for sulfur transfer is an alternate catalytic path. SEQUENCE CAUTION: Sequence=CAI13492.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BTM9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
