ID:USE1_HUMAN DESCRIPTION: RecName: Full=Vesicle transport protein USE1; AltName: Full=Putative MAPK-activating protein PM26; AltName: Full=USE1-like protein; AltName: Full=p31; FUNCTION: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. SUBUNIT: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. SIMILARITY: Belongs to the USE1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZ43
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007041 lysosomal transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0030163 protein catabolic process GO:0032940 secretion by cell GO:0006888 ER to Golgi vesicle-mediated transport
AB097050 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: PM26. AF220052 - Homo sapiens uncharacterized hematopoietic stem/progenitor cells protein MDS032 mRNA, complete cds. AK074683 - Homo sapiens cDNA FLJ90202 fis, clone MAMMA1001634. BC006005 - Homo sapiens unconventional SNARE in the ER 1 homolog (S. cerevisiae), mRNA (cDNA clone MGC:14828 IMAGE:4279653), complete cds. BC008455 - Homo sapiens unconventional SNARE in the ER 1 homolog (S. cerevisiae), mRNA (cDNA clone MGC:14702 IMAGE:4247241), complete cds. CU675221 - Synthetic construct Homo sapiens gateway clone IMAGE:100016699 5' read USE1 mRNA. KJ902888 - Synthetic construct Homo sapiens clone ccsbBroadEn_12282 USE1 gene, encodes complete protein. AB590103 - Synthetic construct DNA, clone: pFN21AE1131, Homo sapiens USE1 gene for unconventional SNARE in the ER 1 homolog, without stop codon, in Flexi system. AM393803 - Synthetic construct Homo sapiens clone IMAGE:100002131 for hypothetical protein (MDS032 gene). EU446821 - Synthetic construct Homo sapiens clone IMAGE:100069991; IMAGE:100012030; FLH258276.01L uncharacterized hematopoietic stem/progenitor cells protein MDS032 (MDS032) gene, encodes complete protein. KJ894273 - Synthetic construct Homo sapiens clone ccsbBroadEn_03667 USE1 gene, encodes complete protein.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NZ43 (Reactome details) participates in the following event(s):
R-HSA-6811422 NSF ATPase activity dissociates cis-SNARE at the ER R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
