Human Gene USP11 (ENST00000377107.7_8) from GENCODE V47lift37
  Description: ubiquitin specific peptidase 11 (from RefSeq NM_001371072.1)
Gencode Transcript: ENST00000377107.7_8
Gencode Gene: ENSG00000102226.10_14
Transcript (Including UTRs)
   Position: hg19 chrX:47,092,408-47,107,727 Size: 15,320 Total Exon Count: 21 Strand: +
Coding Region
   Position: hg19 chrX:47,092,443-47,107,329 Size: 14,887 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:47,092,408-47,107,727)mRNA (may differ from genome)Protein (920 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: G5E9A6_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase; EC=3.4.19.12;
CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
SIMILARITY: Belongs to the peptidase C19 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 112.38 RPKM in Brain - Cortex
Total median expression: 1931.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.4035-0.240 Picture PostScript Text
3' UTR -102.60398-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006615 - Pept_C19_DUSP
IPR018200 - Pept_C19ubi-hydrolase_C_CS
IPR001394 - Peptidase_C19

Pfam Domains:
PF00443 - Ubiquitin carboxyl-terminal hydrolase
PF06337 - DUSP domain
PF13423 - Ubiquitin carboxyl-terminal hydrolase
PF14533 - Ubiquitin-specific protease C-terminal
PF14836 - Ubiquitin-like domain

SCOP Domains:
54001 - Cysteine proteinases
143791 - DUSP-like

ModBase Predicted Comparative 3D Structure on G5E9A6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004843 thiol-dependent ubiquitin-specific protease activity
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Biological Process:
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Cellular Component:
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC140849 - Homo sapiens ubiquitin specific peptidase 11, mRNA (cDNA clone MGC:176526 IMAGE:9021717), complete cds.
KJ892481 - Synthetic construct Homo sapiens clone ccsbBroadEn_01875 USP11 gene, encodes complete protein.
AK055588 - Homo sapiens cDNA FLJ31026 fis, clone HLUNG2000549, highly similar to Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.1.2.15).
AK098394 - Homo sapiens cDNA FLJ25528 fis, clone CBR07442, highly similar to UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 11 (EC 3.1.2.15).
BC073960 - Homo sapiens ubiquitin specific peptidase 11, mRNA (cDNA clone IMAGE:6182961), with apparent retained intron.
BC063668 - Homo sapiens ubiquitin specific peptidase 11, mRNA (cDNA clone IMAGE:4180680), partial cds.
AB073597 - Homo sapiens usp11 mRNA for deubiquitinating enzyme, complete cds.
BC000350 - Homo sapiens ubiquitin specific peptidase 11, mRNA (cDNA clone IMAGE:2961383), partial cds.
AB385092 - Synthetic construct DNA, clone: pF1KB5390, Homo sapiens USP11 gene for ubiquitin carboxyl-terminal hydrolase 11, complete cds, without stop codon, in Flexi system.
JD027528 - Sequence 8552 from Patent EP1572962.
JD035719 - Sequence 16743 from Patent EP1572962.
U44839 - Human putative ubiquitin C-terminal hydrolase (UHX1) mRNA, complete cds.
AK294635 - Homo sapiens cDNA FLJ61237 complete cds, highly similar to Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.1.2.15).
JD166067 - Sequence 147091 from Patent EP1572962.
JD023991 - Sequence 5015 from Patent EP1572962.
JD435656 - Sequence 416680 from Patent EP1572962.
AK092258 - Homo sapiens cDNA FLJ34939 fis, clone NT2RP7006619, highly similar to UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 11 (EC 3.1.2.15).
DQ581100 - Homo sapiens piRNA piR-49212, complete sequence.
JD310235 - Sequence 291259 from Patent EP1572962.
JD455362 - Sequence 436386 from Patent EP1572962.
JD092149 - Sequence 73173 from Patent EP1572962.
JD282142 - Sequence 263166 from Patent EP1572962.
JD068899 - Sequence 49923 from Patent EP1572962.
JD394018 - Sequence 375042 from Patent EP1572962.
JD489273 - Sequence 470297 from Patent EP1572962.
JD429812 - Sequence 410836 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000377107.1, ENST00000377107.2, ENST00000377107.3, ENST00000377107.4, ENST00000377107.5, ENST00000377107.6, G5E9A6, G5E9A6_HUMAN, hCG_17279 , NM_001371072, uc318nkf.1, uc318nkf.2, USP11
UCSC ID: ENST00000377107.7_8
RefSeq Accession: NM_001371072.1
Protein: G5E9A6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.