Human Gene USP14 (ENST00000261601.8_4) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: UBP14_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase 14; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 14; AltName: Full=Ubiquitin thioesterase 14; AltName: Full=Ubiquitin-specific-processing protease 14;
FUNCTION: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
SUBUNIT: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1.
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein.
SIMILARITY: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
SIMILARITY: Contains 1 ubiquitin-like domain.
CAUTION: Was originally (Ref.1) thought to be a guanine tRNA- ribosyltransferase.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR018200 - Pept_C19ubi-hydrolase_C_CS
IPR001394 - Peptidase_C19
IPR000626 - Ubiquitin
IPR019954 - Ubiquitin_CS
IPR019955 - Ubiquitin_supergroup
Pfam Domains:
PF00443 - Ubiquitin carboxyl-terminal hydrolase
PF13423 - Ubiquitin carboxyl-terminal hydrolase
SCOP Domains:
54236 - Ubiquitin-like
54001 - Cysteine proteinases
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P54578
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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LF210968 - JP 2014500723-A/18471: Polycomb-Associated Non-Coding RNAs.
MA446545 - JP 2018138019-A/18471: Polycomb-Associated Non-Coding RNAs.
LF385231 - JP 2014500723-A/192734: Polycomb-Associated Non-Coding RNAs.
AK297605 - Homo sapiens cDNA FLJ53450 complete cds, highly similar to Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15).
AK315438 - Homo sapiens cDNA, FLJ96494, highly similar to Homo sapiens ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (USP14), mRNA.
BC003556 - Homo sapiens ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), mRNA (cDNA clone MGC:1453 IMAGE:3547183), complete cds.
AK095516 - Homo sapiens cDNA FLJ38197 fis, clone FCBBF1000367, highly similar to Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15).
JD405080 - Sequence 386104 from Patent EP1572962.
U30888 - Human tRNA-guanine transglycosylase mRNA, complete cds.
LF342689 - JP 2014500723-A/150192: Polycomb-Associated Non-Coding RNAs.
JD403981 - Sequence 385005 from Patent EP1572962.
AB528508 - Synthetic construct DNA, clone: pF1KB4675, Homo sapiens USP14 gene for ubiquitin specific peptidase 14, without stop codon, in Flexi system.
KJ892686 - Synthetic construct Homo sapiens clone ccsbBroadEn_02080 USP14 gene, encodes complete protein.
DQ893762 - Synthetic construct Homo sapiens clone IMAGE:100008222; FLH164302.01L; RZPDo839E11161D ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (USP14) gene, encodes complete protein.
DQ890594 - Synthetic construct clone IMAGE:100003224; FLH164306.01X; RZPDo839E11162D ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (USP14) gene, encodes complete protein.
CU678498 - Synthetic construct Homo sapiens gateway clone IMAGE:100020282 5' read USP14 mRNA.
BT007183 - Homo sapiens ubiquitin specific protease 14 (tRNA-guanine transglycosylase) mRNA, complete cds.
LF342685 - JP 2014500723-A/150188: Polycomb-Associated Non-Coding RNAs.
LF342677 - JP 2014500723-A/150180: Polycomb-Associated Non-Coding RNAs.
LF342675 - JP 2014500723-A/150178: Polycomb-Associated Non-Coding RNAs.
LF342674 - JP 2014500723-A/150177: Polycomb-Associated Non-Coding RNAs.
LF342673 - JP 2014500723-A/150176: Polycomb-Associated Non-Coding RNAs.
LF342672 - JP 2014500723-A/150175: Polycomb-Associated Non-Coding RNAs.
JD238837 - Sequence 219861 from Patent EP1572962.
JD019511 - Sequence 535 from Patent EP1572962.
LF342671 - JP 2014500723-A/150174: Polycomb-Associated Non-Coding RNAs.
JD545329 - Sequence 526353 from Patent EP1572962.
JD035183 - Sequence 16207 from Patent EP1572962.
JD501097 - Sequence 482121 from Patent EP1572962.
JD557228 - Sequence 538252 from Patent EP1572962.
JD527460 - Sequence 508484 from Patent EP1572962.
JD115763 - Sequence 96787 from Patent EP1572962.
LF342670 - JP 2014500723-A/150173: Polycomb-Associated Non-Coding RNAs.
JD061216 - Sequence 42240 from Patent EP1572962.
JD202432 - Sequence 183456 from Patent EP1572962.
JD422246 - Sequence 403270 from Patent EP1572962.
JD359158 - Sequence 340182 from Patent EP1572962.
JD313926 - Sequence 294950 from Patent EP1572962.
JD556109 - Sequence 537133 from Patent EP1572962.
JD554691 - Sequence 535715 from Patent EP1572962.
JD122986 - Sequence 104010 from Patent EP1572962.
JD432534 - Sequence 413558 from Patent EP1572962.
JD294203 - Sequence 275227 from Patent EP1572962.
JD541104 - Sequence 522128 from Patent EP1572962.
JD291908 - Sequence 272932 from Patent EP1572962.
JD500536 - Sequence 481560 from Patent EP1572962.
JD556422 - Sequence 537446 from Patent EP1572962.
JD522356 - Sequence 503380 from Patent EP1572962.
JD319523 - Sequence 300547 from Patent EP1572962.
JD400997 - Sequence 382021 from Patent EP1572962.
JD548172 - Sequence 529196 from Patent EP1572962.
JD548173 - Sequence 529197 from Patent EP1572962.
JD417777 - Sequence 398801 from Patent EP1572962.
JD410274 - Sequence 391298 from Patent EP1572962.
JD529617 - Sequence 510641 from Patent EP1572962.
JD170095 - Sequence 151119 from Patent EP1572962.
JD170096 - Sequence 151120 from Patent EP1572962.
JD306966 - Sequence 287990 from Patent EP1572962.
JD322750 - Sequence 303774 from Patent EP1572962.
JD400376 - Sequence 381400 from Patent EP1572962.
JD400377 - Sequence 381401 from Patent EP1572962.
JD424825 - Sequence 405849 from Patent EP1572962.
JD366641 - Sequence 347665 from Patent EP1572962.
JD517860 - Sequence 498884 from Patent EP1572962.
AK098497 - Homo sapiens cDNA FLJ25631 fis, clone STM03742.
LF342669 - JP 2014500723-A/150172: Polycomb-Associated Non-Coding RNAs.
LF342668 - JP 2014500723-A/150171: Polycomb-Associated Non-Coding RNAs.
MA620808 - JP 2018138019-A/192734: Polycomb-Associated Non-Coding RNAs.
MA578266 - JP 2018138019-A/150192: Polycomb-Associated Non-Coding RNAs.
MA578262 - JP 2018138019-A/150188: Polycomb-Associated Non-Coding RNAs.
MA578254 - JP 2018138019-A/150180: Polycomb-Associated Non-Coding RNAs.
MA578252 - JP 2018138019-A/150178: Polycomb-Associated Non-Coding RNAs.
MA578251 - JP 2018138019-A/150177: Polycomb-Associated Non-Coding RNAs.
MA578250 - JP 2018138019-A/150176: Polycomb-Associated Non-Coding RNAs.
MA578249 - JP 2018138019-A/150175: Polycomb-Associated Non-Coding RNAs.
MA578248 - JP 2018138019-A/150174: Polycomb-Associated Non-Coding RNAs.
MA578247 - JP 2018138019-A/150173: Polycomb-Associated Non-Coding RNAs.
MA578246 - JP 2018138019-A/150172: Polycomb-Associated Non-Coding RNAs.
MA578245 - JP 2018138019-A/150171: Polycomb-Associated Non-Coding RNAs.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: B7Z4N8, ENST00000261601.1, ENST00000261601.2, ENST00000261601.3, ENST00000261601.4, ENST00000261601.5, ENST00000261601.6, ENST00000261601.7, J3QRZ5, NM_005151, P54578, Q53XY5, TGT, UBP14_HUMAN, uc317grp.1, uc317grp.2
UCSC ID: ENST00000261601.8_4
RefSeq Accession: NM_005151.4
Protein: P54578
(aka UBP14_HUMAN or UB14_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
