ID:UBP22_HUMAN DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase 22; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 22; AltName: Full=Ubiquitin thioesterase 22; AltName: Full=Ubiquitin-specific-processing protease 22; FUNCTION: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). SUBUNIT: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver. SIMILARITY: Belongs to the peptidase C19 family. UBP8 subfamily. SIMILARITY: Contains 1 UBP-type zinc finger. SEQUENCE CAUTION: Sequence=AAH25317.1; Type=Frameshift; Positions=355; Sequence=BAA83015.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00443 - Ubiquitin carboxyl-terminal hydrolase PF02148 - Zn-finger in ubiquitin-hydrolases and other protein PF13423 - Ubiquitin carboxyl-terminal hydrolase
ModBase Predicted Comparative 3D Structure on Q9UPT9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
