ID:UBP45_HUMAN DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase 45; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 45; AltName: Full=Ubiquitin thioesterase 45; AltName: Full=Ubiquitin-specific-processing protease 45; CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). TISSUE SPECIFICITY: Broadly expressed, with highest levels in ovary, skeletal muscle and spleen. SIMILARITY: Belongs to the peptidase C19 family. SIMILARITY: Contains 1 UBP-type zinc finger. SEQUENCE CAUTION: Sequence=CAI17192.1; Type=Erroneous gene model prediction; Sequence=CAI19761.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q70EL2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004843 thiol-dependent ubiquitin-specific protease activity GO:0008233 peptidase activity GO:0008234 cysteine-type peptidase activity GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0046872 metal ion binding
Biological Process: GO:0006281 DNA repair GO:0006508 proteolysis GO:0006511 ubiquitin-dependent protein catabolic process GO:0016579 protein deubiquitination GO:0070911 global genome nucleotide-excision repair
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
