ID:UT14A_HUMAN DESCRIPTION: RecName: Full=U3 small nucleolar RNA-associated protein 14 homolog A; AltName: Full=Antigen NY-CO-16; AltName: Full=Serologically defined colon cancer antigen 16; FUNCTION: May be required for ribosome biogenesis (By similarity). INTERACTION: O95257:GADD45G; NbExp=2; IntAct=EBI-473284, EBI-448202; SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X- chromosome silencing during male meiosis. SIMILARITY: Belongs to the UTP14 family. SEQUENCE CAUTION: Sequence=CAI42909.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BVJ6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP896571 - Sequence 1435 from Patent EP3253886. AK291918 - Homo sapiens cDNA FLJ76903 complete cds, highly similar to Homo sapiens UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) (UTP14A), mRNA. AK298578 - Homo sapiens cDNA FLJ53406 complete cds, highly similar to U3 small nucleolar RNA-associated protein 14 homolog A. BC009649 - Homo sapiens UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast), mRNA (cDNA clone MGC:5577 IMAGE:3459192), complete cds. BC001149 - Homo sapiens UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast), mRNA (cDNA clone MGC:1291 IMAGE:3355662), complete cds. AK304563 - Homo sapiens cDNA FLJ54249 complete cds, highly similar to U3 small nucleolar RNA-associated protein 14 homolog A. BC014987 - Homo sapiens UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast), mRNA (cDNA clone MGC:23217 IMAGE:4901477), complete cds. AF039694 - Homo sapiens antigen NY-CO-16 mRNA, complete cds. CU679427 - Synthetic construct Homo sapiens gateway clone IMAGE:100020072 5' read UTP14A mRNA. AB590128 - Synthetic construct DNA, clone: pFN21AE1533, Homo sapiens UTP14A gene for UTP14, U3 small nucleolar ribonucleoprotein, homolog A, without stop codon, in Flexi system. DQ892549 - Synthetic construct clone IMAGE:100005179; FLH187385.01X; RZPDo839G0972D UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) (UTP14A) gene, encodes complete protein. DQ895760 - Synthetic construct Homo sapiens clone IMAGE:100010220; FLH187381.01L; RZPDo839G0962D UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) (UTP14A) gene, encodes complete protein. KJ893140 - Synthetic construct Homo sapiens clone ccsbBroadEn_02534 UTP14A gene, encodes complete protein. AK094408 - Homo sapiens cDNA FLJ37089 fis, clone BRACE2017298, weakly similar to Translation initiation factor eIF3. LF211469 - JP 2014500723-A/18972: Polycomb-Associated Non-Coding RNAs. LF380016 - JP 2014500723-A/187519: Polycomb-Associated Non-Coding RNAs. LF380017 - JP 2014500723-A/187520: Polycomb-Associated Non-Coding RNAs. LF380018 - JP 2014500723-A/187521: Polycomb-Associated Non-Coding RNAs. LF380019 - JP 2014500723-A/187522: Polycomb-Associated Non-Coding RNAs. LF380020 - JP 2014500723-A/187523: Polycomb-Associated Non-Coding RNAs. LF380021 - JP 2014500723-A/187524: Polycomb-Associated Non-Coding RNAs. JD455241 - Sequence 436265 from Patent EP1572962. JD374814 - Sequence 355838 from Patent EP1572962. MA447046 - JP 2018138019-A/18972: Polycomb-Associated Non-Coding RNAs. MA615593 - JP 2018138019-A/187519: Polycomb-Associated Non-Coding RNAs. MA615594 - JP 2018138019-A/187520: Polycomb-Associated Non-Coding RNAs. MA615595 - JP 2018138019-A/187521: Polycomb-Associated Non-Coding RNAs. MA615596 - JP 2018138019-A/187522: Polycomb-Associated Non-Coding RNAs. MA615597 - JP 2018138019-A/187523: Polycomb-Associated Non-Coding RNAs. MA615598 - JP 2018138019-A/187524: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BVJ6 (Reactome details) participates in the following event(s):
R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
