Human Gene UTS2 (ENST00000361696.10_9) from GENCODE V47lift37
  Description: urotensin 2, transcript variant 2 (from RefSeq NM_006786.4)
Gencode Transcript: ENST00000361696.10_9
Gencode Gene: ENSG00000049247.14_11
Transcript (Including UTRs)
   Position: hg19 chr1:7,907,672-7,913,125 Size: 5,454 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr1:7,907,826-7,913,063 Size: 5,238 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:7,907,672-7,913,125)mRNA (may differ from genome)Protein (124 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UTS2_HUMAN
DESCRIPTION: RecName: Full=Urotensin-2; AltName: Full=Urotensin II; Short=U-II; Short=UII; Flags: Precursor;
FUNCTION: Highly potent vasoconstrictor.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Brain specific.
SIMILARITY: Belongs to the urotensin-2 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: UTS2
Diseases sorted by gene-association score: portal hypertension (12), congestive heart failure (7), liver cirrhosis (4), hepatic vascular disease (4), pulmonary hypertension (4), heart disease (3), pheochromocytoma (2), hypertension, essential (2), diabetes mellitus, noninsulin-dependent (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.48 RPKM in Brain - Hypothalamus
Total median expression: 2.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.6062-0.171 Picture PostScript Text
3' UTR -22.40154-0.145 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001483 - Urotensin_II

Pfam Domains:
PF02083 - Urotensin II

ModBase Predicted Comparative 3D Structure on O95399
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005179 hormone activity

Biological Process:
GO:0006936 muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008217 regulation of blood pressure
GO:0010469 regulation of receptor activity
GO:0097746 regulation of blood vessel diameter

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC025776 - Homo sapiens urotensin 2, mRNA (cDNA clone IMAGE:5223016), partial cds.
AY358375 - Homo sapiens clone DNA59214 UTS2 (UNQ525) mRNA, complete cds.
AF104118 - Homo sapiens urotensin II precursor, mRNA, complete cds.
BC126443 - Homo sapiens urotensin 2, mRNA (cDNA clone MGC:161721 IMAGE:8992159), complete cds.
BC171734 - Homo sapiens cDNA clone IMAGE:9052404.
JD050025 - Sequence 31049 from Patent EP1572962.
JD552401 - Sequence 533425 from Patent EP1572962.
AF140630 - Homo sapiens urotensin-II mRNA, complete cds.
KJ902175 - Synthetic construct Homo sapiens clone ccsbBroadEn_11569 UTS2 gene, encodes complete protein.
KR711679 - Synthetic construct Homo sapiens clone CCSBHm_00028459 UTS2 (UTS2) mRNA, encodes complete protein.
HQ258706 - Synthetic construct Homo sapiens clone IMAGE:100072736 Unknown protein gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95399 (Reactome details) participates in the following event(s):

R-HSA-445113 Urotensin-2 receptor binds urotensin-2 and 2B
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000361696.1, ENST00000361696.2, ENST00000361696.3, ENST00000361696.4, ENST00000361696.5, ENST00000361696.6, ENST00000361696.7, ENST00000361696.8, ENST00000361696.9, NM_006786, O95399, Q5H8X7, Q6UXF6, Q9UKP7, uc318cgq.1, uc318cgq.2, UNQ525/PRO1068, UTS2_HUMAN
UCSC ID: ENST00000361696.10_9
RefSeq Accession: NM_006786.4
Protein: O95399 (aka UTS2_HUMAN or UR2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.