Human Gene UTS2R (ENST00000313135.5_4) from GENCODE V47lift37
  Description: urotensin 2 receptor, transcript variant 1 (from RefSeq NM_018949.3)
Gencode Transcript: ENST00000313135.5_4
Gencode Gene: ENSG00000181408.5_5
Transcript (Including UTRs)
   Position: hg19 chr17:80,329,641-80,335,334 Size: 5,694 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr17:80,332,201-80,333,370 Size: 1,170 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:80,329,641-80,335,334)mRNA (may differ from genome)Protein (389 aa)
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UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UR2R_HUMAN
DESCRIPTION: RecName: Full=Urotensin-2 receptor; Short=UR-2-R; AltName: Full=G-protein coupled receptor 14; AltName: Full=Urotensin II receptor; Short=UR-II-R;
FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Most abundant expression in the heart and pancreas.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: UTS2R
Diseases sorted by gene-association score: amyotrophic lateral sclerosis 3 (5), pheochromocytoma (2), amyotrophic lateral sclerosis 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.51 RPKM in Testis
Total median expression: 8.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -271.20551-0.492 Picture PostScript Text
3' UTR -828.201964-0.422 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000670 - Urot_II_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9UKP6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001604 urotensin II receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0003105 negative regulation of glomerular filtration
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0030307 positive regulation of cell growth
GO:0035811 negative regulation of urine volume
GO:0035814 negative regulation of renal sodium excretion
GO:0042493 response to drug
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0045907 positive regulation of vasoconstriction
GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep
GO:0048146 positive regulation of fibroblast proliferation
GO:0097746 regulation of blood vessel diameter

Cellular Component:
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0055037 recycling endosome


-  Descriptions from all associated GenBank mRNAs
  BC136490 - Homo sapiens urotensin 2 receptor, mRNA (cDNA clone MGC:168102 IMAGE:9020479), complete cds.
JD396604 - Sequence 377628 from Patent EP1572962.
KJ896915 - Synthetic construct Homo sapiens clone ccsbBroadEn_06309 UTS2R gene, encodes complete protein.
DQ571050 - Homo sapiens piRNA piR-31162, complete sequence.
JD265711 - Sequence 246735 from Patent EP1572962.
DQ594916 - Homo sapiens piRNA piR-61028, complete sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UKP6 (Reactome details) participates in the following event(s):

R-HSA-445113 Urotensin-2 receptor binds urotensin-2 and 2B
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RMV8, ENST00000313135.1, ENST00000313135.2, ENST00000313135.3, ENST00000313135.4, GPR14, NM_018949, Q9UKP6, uc317piv.1, uc317piv.2, UR2R_HUMAN
UCSC ID: ENST00000313135.5_4
RefSeq Accession: NM_018949.3
Protein: Q9UKP6 (aka UR2R_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.