ID:VAPA_HUMAN DESCRIPTION: RecName: Full=Vesicle-associated membrane protein-associated protein A; Short=VAMP-A; Short=VAMP-associated protein A; Short=VAP-A; AltName: Full=33 kDa VAMP-associated protein; Short=VAP-33; FUNCTION: May play a role in vesicle trafficking. SUBUNIT: Homodimer, and heterodimer with VAPB. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal domain of OCLN. Interacts with OSBPL1A. Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation. Interacts with OSBP. Interacts (via C-terminus) with RSAD2/viperin (via C- terminus). Interacts with HCV protein NS5A and NS5B. INTERACTION: P00533:EGFR; NbExp=2; IntAct=EBI-1059156, EBI-297353; Q5T4F4:ZFYVE27; NbExp=5; IntAct=EBI-1059156, EBI-3892947; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. SIMILARITY: Contains 1 MSP domain. SEQUENCE CAUTION: Sequence=AAD09742.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF72105.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BG488667; Type=Frameshift; Positions=72, 207, 241;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P0L0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0008219 cell death GO:0030148 sphingolipid biosynthetic process GO:0031175 neuron projection development GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043312 neutrophil degranulation GO:0044791 positive regulation by host of viral release from host cell GO:0044828 negative regulation by host of viral genome replication GO:0044829 positive regulation by host of viral genome replication GO:0061025 membrane fusion GO:0070972 protein localization to endoplasmic reticulum GO:0090114 COPII-coated vesicle budding GO:0007029 endoplasmic reticulum organization GO:0034975 protein folding in endoplasmic reticulum
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
