ID:VCAM1_HUMAN DESCRIPTION: RecName: Full=Vascular cell adhesion protein 1; Short=V-CAM 1; Short=VCAM-1; AltName: Full=INCAM-100; AltName: CD_antigen=CD106; Flags: Precursor; FUNCTION: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. SUBUNIT: Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. INDUCTION: By cytokines (e.g. IL-1, TNF-alpha). DOMAIN: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion. PTM: Sialoglycoprotein. SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. WEB RESOURCE: Name=Wikipedia; Note=VCAM1 entry; URL="http://en.wikipedia.org/wiki/VCAM1"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/vcam1/"; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=VCAM-1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_266";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P19320
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK291732 - Homo sapiens cDNA FLJ76891 complete cds, highly similar to Homo sapiens vascular cell adhesion molecule 1 (VCAM1), transcript variant 1, mRNA. AK296692 - Homo sapiens cDNA FLJ55701 complete cds, highly similar to Vascular cell adhesion protein 1 precursor. BC068490 - Homo sapiens vascular cell adhesion molecule 1, mRNA (cDNA clone MGC:87170 IMAGE:30339170), complete cds. AK223266 - Homo sapiens mRNA for vascular cell adhesion molecule 1 isoform a precursor variant, clone: SYN01792. M30257 - Human vascular cell adhesion molecule 1 mRNA, complete cds. BC017276 - Homo sapiens vascular cell adhesion molecule 1, mRNA (cDNA clone MGC:29563 IMAGE:4845424), complete cds. BC085003 - Homo sapiens vascular cell adhesion molecule 1, mRNA (cDNA clone MGC:99561 IMAGE:6375943), complete cds. M60335 - Human vascular cell adhesion molecule 1 mRNA, complete cds. AB590609 - Synthetic construct DNA, clone: pFN21AE2075, Homo sapiens VCAM1 gene for vascular cell adhesion molecule 1, without stop codon, in Flexi system. EU831989 - Synthetic construct Homo sapiens clone HAIB:100067018; DKFZo008H0623 vascular cell adhesion molecule 1 protein (VCAM1) gene, encodes complete protein. EU832082 - Synthetic construct Homo sapiens clone HAIB:100067111; DKFZo004H0624 vascular cell adhesion molecule 1 protein (VCAM1) gene, encodes complete protein. X53051 - Human mRNA for vascular cell adhesion molecule 1 (VCAM-1). CU686647 - Synthetic construct Homo sapiens gateway clone IMAGE:100023231 5' read VCAM1 mRNA. KJ892369 - Synthetic construct Homo sapiens clone ccsbBroadEn_01763 VCAM1 gene, encodes complete protein. KR711425 - Synthetic construct Homo sapiens clone CCSBHm_00023521 VCAM1 (VCAM1) mRNA, encodes complete protein. JD252477 - Sequence 233501 from Patent EP1572962. JD559846 - Sequence 540870 from Patent EP1572962. BD277104 - ENDOTHELIAL CELL-LEUKOCYTE ADHESION MOLECULES (ELAMs) AND MOLECULES INVOLVED IN LEUKOCYTE ADHESION (MILAs). BD342999 - ENDOTHELIAL CELL-LEUKOCYTE ADHESION MOLECULES (ELAMs) AND MOLECULES INVOLVED IN LEUKOCYTE ADHESION (MILAs). DL181915 - ENDOTHELIAL CELL-LEUKOCYTE ADHESION MOLECULES (ELAMs) AND MOLECULES INVOLVED IN LEUKOCYTE ADHESION (MILAs). CR749464 - Homo sapiens mRNA; cDNA DKFZp779G2333 (from clone DKFZp779G2333). JD046502 - Sequence 27526 from Patent EP1572962. JD238797 - Sequence 219821 from Patent EP1572962. JD531213 - Sequence 512237 from Patent EP1572962. JA215692 - Sequence 29 from Patent EP2310507. JD137543 - Sequence 118567 from Patent EP1572962. JD500015 - Sequence 481039 from Patent EP1572962. JD363491 - Sequence 344515 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_LairPathway - Cells and Molecules involved in local acute inflammatory response h_lympathway - Adhesion and Diapedesis of Lymphocytes
Reactome (by CSHL, EBI, and GO)
Protein P19320 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
