ID:CSPG2_HUMAN DESCRIPTION: RecName: Full=Versican core protein; AltName: Full=Chondroitin sulfate proteoglycan core protein 2; Short=Chondroitin sulfate proteoglycan 2; AltName: Full=Glial hyaluronate-binding protein; Short=GHAP; AltName: Full=Large fibroblast proteoglycan; AltName: Full=PG-M; Flags: Precursor; FUNCTION: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. SUBUNIT: Interacts with FBLN1 (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. TISSUE SPECIFICITY: Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas. DEVELOPMENTAL STAGE: Disappears after the cartilage development. PTM: Phosphorylation sites are present in the extracellular medium. DISEASE: Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN. SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. SIMILARITY: Contains 1 C-type lectin domain. SIMILARITY: Contains 2 EGF-like domains. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SIMILARITY: Contains 2 Link domains. SIMILARITY: Contains 1 Sushi (CCP/SCR) domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Versican; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_214";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P13611
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001501 skeletal system development GO:0001649 osteoblast differentiation GO:0007155 cell adhesion GO:0007275 multicellular organism development GO:0007417 central nervous system development GO:0008037 cell recognition GO:0008347 glial cell migration GO:0030198 extracellular matrix organization GO:0030206 chondroitin sulfate biosynthetic process GO:0030207 chondroitin sulfate catabolic process GO:0030208 dermatan sulfate biosynthetic process GO:0043687 post-translational protein modification GO:0044267 cellular protein metabolic process
Protein P13611 (Reactome details) participates in the following event(s):
R-HSA-1971487 CHPF,CHSY1,CHSY3 transfer GalNAc to chondroitin R-HSA-1971491 CHPF,CHPF2,CHSY1,CHSY3 transfer GlcA to chondroitin R-HSA-2018682 CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains R-HSA-1889955 B3GATs transfer GlcA to tetrasaccharide linker R-HSA-1889978 B3GALT6 transfers Gal to the tetrasaccharide linker R-HSA-2018659 Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 R-HSA-1889981 B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker R-HSA-1878002 XYLTs transfer Xyl to core protein R-HSA-1971482 The addition of GalNAc to the terminal glucuronate residue forms chondroitin R-HSA-1971483 Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 R-HSA-2022061 Dermatan sulfate can be further sulfated on position 2 of iduronate R-HSA-2424246 Tenascins C, R, (X, N) bind lecticans R-HSA-2022052 Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) R-HSA-2022063 CHST14 transfers SO4(2-) to GalNAc in dermatan or DS R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-2022870 Chondroitin sulfate biosynthesis R-HSA-3595177 Defective CHSY1 causes TPBS R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3595172 Defective CHST3 causes SEDCJD R-HSA-2022923 Dermatan sulfate biosynthesis R-HSA-2024101 CS/DS degradation R-HSA-3000178 ECM proteoglycans R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-1474244 Extracellular matrix organization R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-3781865 Diseases of glycosylation R-HSA-392499 Metabolism of proteins R-HSA-597592 Post-translational protein modification R-HSA-71387 Metabolism of carbohydrates R-HSA-1643685 Disease R-HSA-1430728 Metabolism
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Common Gene Haplotype Alleles 
