ID:VDAC1_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent anion-selective channel protein 1; Short=VDAC-1; Short=hVDAC1; AltName: Full=Outer mitochondrial membrane protein porin 1; AltName: Full=Plasmalemmal porin; AltName: Full=Porin 31HL; AltName: Full=Porin 31HM; FUNCTION: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. SUBUNIT: Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein. INTERACTION: P19367:HK1; NbExp=2; IntAct=EBI-354158, EBI-713162; SUBCELLULAR LOCATION: Mitochondrion outer membrane. Cell membrane. TISSUE SPECIFICITY: Heart, liver and skeletal muscle. DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity. SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P21796
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK122953 - Homo sapiens cDNA FLJ16670 fis, clone THYMU3001133, highly similar to Voltage-dependent anion-selective channel protein 1. BC008482 - Homo sapiens voltage-dependent anion channel 1, mRNA (cDNA clone MGC:14782 IMAGE:4332199), complete cds. BC090042 - Homo sapiens voltage-dependent anion channel 1, mRNA (cDNA clone MGC:111064 IMAGE:30395350), complete cds. BC071168 - Homo sapiens voltage-dependent anion channel 1, mRNA (cDNA clone MGC:88007 IMAGE:6023095), complete cds. CS607875 - Sequence 4 from Patent WO2007043049. HM035071 - Homo sapiens sperm binding protein 1a mRNA, complete cds. L06132 - Human voltage-dependent anion channel isoform 1 (VDAC) mRNA, complete cds. AK095989 - Homo sapiens cDNA FLJ38670 fis, clone HSYRA2000190, highly similar to Voltage-dependent anion-selective channel protein 1. JD304568 - Sequence 285592 from Patent EP1572962. JD270252 - Sequence 251276 from Patent EP1572962. JD300984 - Sequence 282008 from Patent EP1572962. AK293639 - Homo sapiens cDNA FLJ57715 complete cds, highly similar to Voltage-dependent anion-selective channel protein 1. JD227421 - Sequence 208445 from Patent EP1572962. DQ893183 - Synthetic construct clone IMAGE:100005813; FLH194827.01X; RZPDo839F0680D voltage-dependent anion channel 1 (VDAC1) gene, encodes complete protein. KJ892370 - Synthetic construct Homo sapiens clone ccsbBroadEn_01764 VDAC1 gene, encodes complete protein. DQ896492 - Synthetic construct Homo sapiens clone IMAGE:100010952; FLH194823.01L; RZPDo839F0670D voltage-dependent anion channel 1 (VDAC1) gene, encodes complete protein. AB590378 - Synthetic construct DNA, clone: pFN21AE2162, Homo sapiens VDAC1 gene for voltage-dependent anion channel 1, without stop codon, in Flexi system. JD274438 - Sequence 255462 from Patent EP1572962. JD142956 - Sequence 123980 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P21796 (Reactome details) participates in the following event(s):
R-HSA-5205682 Parkin promotes the ubiquitination of mitochondrial substrates R-HSA-5205673 p62 binds ubiquitinated mitochondrial substrates R-HSA-1268025 SAM50 complex inserts proteins into mitochondrial outer membrane R-HSA-5205649 p62 links damaged mitochondria to LC3 R-HSA-8949145 VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space R-HSA-5696872 USP30 deubiquitinates Ub-MOM proteins R-HSA-5205663 LC3 binds the autophagosome membrane Atg5-Atg12 complex R-HSA-5205685 Pink/Parkin Mediated Mitophagy R-HSA-1268020 Mitochondrial protein import R-HSA-5205647 Mitophagy R-HSA-392499 Metabolism of proteins R-HSA-8949215 Mitochondrial calcium ion transport R-HSA-5689880 Ub-specific processing proteases R-HSA-382551 Transport of small molecules R-HSA-5688426 Deubiquitination R-HSA-597592 Post-translational protein modification
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
