ID:VDAC2_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent anion-selective channel protein 2; Short=VDAC-2; Short=hVDAC2; AltName: Full=Outer mitochondrial membrane protein porin 2; FUNCTION: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. SUBUNIT: Interacts with hexokinases (By similarity). INTERACTION: Q96A26:FAM162A; NbExp=2; IntAct=EBI-354022, EBI-6123466; SUBCELLULAR LOCATION: Mitochondrion outer membrane. TISSUE SPECIFICITY: Expressed in all tissues examined. DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity). SIMILARITY: Belongs to the eukaryotic mitochondrial porin family. SEQUENCE CAUTION: Sequence=CAH73106.1; Type=Erroneous gene model prediction; Sequence=CAI40910.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P45880
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006820 anion transport GO:0007339 binding of sperm to zona pellucida GO:0015698 inorganic anion transport GO:0032272 negative regulation of protein polymerization GO:0055085 transmembrane transport GO:0098656 anion transmembrane transport GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Protein P45880 (Reactome details) participates in the following event(s):
R-HSA-8949145 VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space R-HSA-5696872 USP30 deubiquitinates Ub-MOM proteins R-HSA-8949215 Mitochondrial calcium ion transport R-HSA-5689880 Ub-specific processing proteases R-HSA-382551 Transport of small molecules R-HSA-5688426 Deubiquitination R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
