ID:VDAC3_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent anion-selective channel protein 3; Short=VDAC-3; Short=hVDAC3; AltName: Full=Outer mitochondrial membrane protein porin 3; FUNCTION: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). SUBCELLULAR LOCATION: Mitochondrion outer membrane. TISSUE SPECIFICITY: Widely expressed. Highest in testis. DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity). SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y277
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF038962 - Homo sapiens voltage dependent anion channel protein mRNA, complete cds. AK307224 - Homo sapiens cDNA, FLJ97172. AK308760 - Homo sapiens cDNA, FLJ98801. AK058201 - Homo sapiens cDNA FLJ25472 fis, clone TST09616, highly similar to VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 3. BC056870 - Homo sapiens voltage-dependent anion channel 3, mRNA (cDNA clone MGC:64870 IMAGE:6163890), complete cds. BC002456 - Homo sapiens cDNA clone IMAGE:3343379, **** WARNING: chimeric clone ****. HQ448061 - Synthetic construct Homo sapiens clone IMAGE:100071440; CCSB012000_01 voltage-dependent anion channel 3 (VDAC3) gene, encodes complete protein. KJ892372 - Synthetic construct Homo sapiens clone ccsbBroadEn_01766 VDAC3 gene, encodes complete protein. AM393322 - Synthetic construct Homo sapiens clone IMAGE:6163890.1E2 for hypothetical protein (VDAC3 gene). AM393569 - Synthetic construct Homo sapiens clone IMAGE:6163890.1E1 for hypothetical protein (VDAC3 gene). CU691170 - Synthetic construct Homo sapiens gateway clone IMAGE:100021700 5' read VDAC3 mRNA. U90943 - Homo sapiens voltage dependent anion channel form 3 mRNA, complete cds. AK095798 - Homo sapiens cDNA FLJ38479 fis, clone FEBRA2022787. LF331097 - JP 2014500723-A/138600: Polycomb-Associated Non-Coding RNAs. JD477623 - Sequence 458647 from Patent EP1572962. JD494894 - Sequence 475918 from Patent EP1572962. JD537725 - Sequence 518749 from Patent EP1572962. MA566674 - JP 2018138019-A/138600: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y277 (Reactome details) participates in the following event(s):
R-HSA-8949145 VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space R-HSA-5696872 USP30 deubiquitinates Ub-MOM proteins R-HSA-8949215 Mitochondrial calcium ion transport R-HSA-5689880 Ub-specific processing proteases R-HSA-382551 Transport of small molecules R-HSA-5688426 Deubiquitination R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
