Human Gene VEGFB (ENST00000309422.7_6) from GENCODE V47lift37
  Description: vascular endothelial growth factor B, transcript variant VEGFB-186 (from RefSeq NM_003377.5)
Gencode Transcript: ENST00000309422.7_6
Gencode Gene: ENSG00000173511.10_9
Transcript (Including UTRs)
   Position: hg19 chr11:64,002,056-64,006,736 Size: 4,681 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr11:64,002,306-64,005,105 Size: 2,800 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:64,002,056-64,006,736)mRNA (may differ from genome)Protein (207 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q7LAP4_HUMAN
DESCRIPTION: SubName: Full=Vascular endothelial growth factor B; SubName: Full=Vascular endothelial growth factor B isoform VEGF-B186;
SIMILARITY: Belongs to the PDGF/VEGF growth factor family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: VEGFB
Diseases sorted by gene-association score: kuhnt-junius degeneration (6), macular degeneration, age-related, 1 (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 139.68 RPKM in Adipose - Subcutaneous
Total median expression: 3109.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -165.30250-0.661 Picture PostScript Text
3' UTR -331.20931-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000072 - PD_growth_factor
IPR023581 - PD_growth_factor_CS

Pfam Domains:
PF00341 - PDGF/VEGF domain

SCOP Domains:
57501 - Cystine-knot cytokines

ModBase Predicted Comparative 3D Structure on Q7LAP4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0001525 angiogenesis
GO:0006493 protein O-linked glycosylation
GO:0007507 heart development
GO:0010469 regulation of receptor activity
GO:0042493 response to drug
GO:0060048 cardiac muscle contraction
GO:0060976 coronary vasculature development

Cellular Component:
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  LF211213 - JP 2014500723-A/18716: Polycomb-Associated Non-Coding RNAs.
LQ270814 - Sequence 142 from Patent WO2016071350.
LQ270816 - Sequence 144 from Patent WO2016071350.
BC008818 - Homo sapiens vascular endothelial growth factor B, mRNA (cDNA clone MGC:10373 IMAGE:4053976), complete cds.
FW406919 - NUCLEIC ACID COMPOUNDS FOR INHIBITING VEGF FAMILY GENE EXPRESSION AND USES THEREOF.
JA810032 - Sequence 1165 from Patent EP2468864.
DQ895870 - Synthetic construct Homo sapiens clone IMAGE:100010330; FLH188479.01L; RZPDo839C1063D vascular endothelial growth factor B (VEGFB) gene, encodes complete protein.
DQ895872 - Synthetic construct Homo sapiens clone IMAGE:100010332; FLH263601.01L; RZPDo839C1263D vascular endothelial growth factor B (VEGFB) gene, encodes complete protein.
DQ892633 - Synthetic construct clone IMAGE:100005263; FLH188483.01X; RZPDo839C1073D vascular endothelial growth factor B (VEGFB) gene, encodes complete protein.
U52819 - Human vascular endothelial growth factor B 186 (VEGF-B) precursor, mRNA, complete cds.
U48801 - Human vascular endothelial growth factor B precursor (VEGF-B) mRNA, complete cds.
AB590381 - Synthetic construct DNA, clone: pFN21AE1353, Homo sapiens VEGFB gene for vascular endothelial growth factor B, without stop codon, in Flexi system.
U43368 - Human VEGF related factor isoform VRF186 precursor (VRF) mRNA, complete cds.
KJ892375 - Synthetic construct Homo sapiens clone ccsbBroadEn_01769 VEGFB gene, encodes complete protein.
U43369 - Human VEGF related factor isoform VRF167 precursor (VRF) mRNA, complete cds.
FW553634 - IRNA AGENTS TARGETING VEGF.
HI963340 - Sequence 270 from Patent EP1735009.
HV496579 - JP 2011518117-A/1807: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV982962 - JP 2011188866-A/270: IRNA AGENTS TARGETING VEGF.
HZ402096 - JP 2015177801-A/1807: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ420193 - JP 2014094020-A/270: IRNA AGENTS TARGETING VEGF.
LZ247364 - JP 2016135144-A/270: IRNA AGENTS TARGETING VEGF.
FW553635 - IRNA AGENTS TARGETING VEGF.
FW553636 - IRNA AGENTS TARGETING VEGF.
HI963341 - Sequence 271 from Patent EP1735009.
HI963342 - Sequence 272 from Patent EP1735009.
HV496580 - JP 2011518117-A/1808: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496581 - JP 2011518117-A/1809: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV982963 - JP 2011188866-A/271: IRNA AGENTS TARGETING VEGF.
HV982964 - JP 2011188866-A/272: IRNA AGENTS TARGETING VEGF.
HZ402097 - JP 2015177801-A/1808: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ402098 - JP 2015177801-A/1809: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ420194 - JP 2014094020-A/271: IRNA AGENTS TARGETING VEGF.
HZ420195 - JP 2014094020-A/272: IRNA AGENTS TARGETING VEGF.
LZ247365 - JP 2016135144-A/271: IRNA AGENTS TARGETING VEGF.
LZ247366 - JP 2016135144-A/272: IRNA AGENTS TARGETING VEGF.
FW553637 - IRNA AGENTS TARGETING VEGF.
HI963343 - Sequence 273 from Patent EP1735009.
HV496582 - JP 2011518117-A/1810: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV982965 - JP 2011188866-A/273: IRNA AGENTS TARGETING VEGF.
HZ402099 - JP 2015177801-A/1810: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ420196 - JP 2014094020-A/273: IRNA AGENTS TARGETING VEGF.
LZ247367 - JP 2016135144-A/273: IRNA AGENTS TARGETING VEGF.
LF344630 - JP 2014500723-A/152133: Polycomb-Associated Non-Coding RNAs.
LF344626 - JP 2014500723-A/152129: Polycomb-Associated Non-Coding RNAs.
JD414257 - Sequence 395281 from Patent EP1572962.
JD370680 - Sequence 351704 from Patent EP1572962.
JC476683 - Sequence 12 from Patent EP2766500.
LF401627 - JP 2014530612-A/12: Materials and Methods Related to Ovarian Cancer.
JD096072 - Sequence 77096 from Patent EP1572962.
JD248734 - Sequence 229758 from Patent EP1572962.
JD423724 - Sequence 404748 from Patent EP1572962.
JD278174 - Sequence 259198 from Patent EP1572962.
JD414157 - Sequence 395181 from Patent EP1572962.
DL491736 - Novel nucleic acids.
JD331364 - Sequence 312388 from Patent EP1572962.
JD348592 - Sequence 329616 from Patent EP1572962.
DL490316 - Novel nucleic acids.
JD281766 - Sequence 262790 from Patent EP1572962.
JD528346 - Sequence 509370 from Patent EP1572962.
JD095732 - Sequence 76756 from Patent EP1572962.
JD198696 - Sequence 179720 from Patent EP1572962.
JD294510 - Sequence 275534 from Patent EP1572962.
LF344623 - JP 2014500723-A/152126: Polycomb-Associated Non-Coding RNAs.
JD062078 - Sequence 43102 from Patent EP1572962.
MA580207 - JP 2018138019-A/152133: Polycomb-Associated Non-Coding RNAs.
MA580203 - JP 2018138019-A/152129: Polycomb-Associated Non-Coding RNAs.
MA580200 - JP 2018138019-A/152126: Polycomb-Associated Non-Coding RNAs.
MA446790 - JP 2018138019-A/18716: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000309422.1, ENST00000309422.2, ENST00000309422.3, ENST00000309422.4, ENST00000309422.5, ENST00000309422.6, NM_003377, Q7LAP4, Q7LAP4_HUMAN, uc317onj.1, uc317onj.2, VEGFB
UCSC ID: ENST00000309422.7_6
RefSeq Accession: NM_003377.5
Protein: Q7LAP4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.