Human Gene VIP (ENST00000367244.8_5) from GENCODE V47lift37
  Description: vasoactive intestinal peptide, transcript variant 1 (from RefSeq NM_003381.4)
Gencode Transcript: ENST00000367244.8_5
Gencode Gene: ENSG00000146469.13_7
Transcript (Including UTRs)
   Position: hg19 chr6:153,071,932-153,080,895 Size: 8,964 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr6:153,073,313-153,078,276 Size: 4,964 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:153,071,932-153,080,895)mRNA (may differ from genome)Protein (170 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: VIP_HUMAN
DESCRIPTION: RecName: Full=VIP peptides; Contains: RecName: Full=Intestinal peptide PHV-42; AltName: Full=Peptide histidine valine 42; Contains: RecName: Full=Intestinal peptide PHM-27; AltName: Full=Peptide histidine methioninamide 27; Contains: RecName: Full=Vasoactive intestinal peptide; Short=VIP; AltName: Full=Vasoactive intestinal polypeptide; Flags: Precursor;
FUNCTION: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
FUNCTION: PHM and PHV also cause vasodilation.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the glucagon family.
WEB RESOURCE: Name=Wikipedia; Note=Vasoactive intestinal peptide entry; URL="http://en.wikipedia.org/wiki/Vasoactive_intestinal_peptide";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: VIP
Diseases sorted by gene-association score: vipoma (36), wdha syndrome (28), vasomotor rhinitis (27), ganglioneuroma (22), chemical colitis (21), pancreatic cholera (18), somatostatinoma (17), cholera (17), fetal alcohol syndrome (16), islet cell tumor (14), impotence (13), subcortical arteriosclerotic encephalopathy (13), glucagonoma (12), ganglioneuroblastoma (12), cluster headache (12), achalasia (12), gastrinoma (11), megaesophagus (10), amyloid neuropathy (10), holoprosencephaly 3 (10), persian gulf syndrome (9), cryptosporidiosis (9), constipation (9), megacolon (9), bronchitis (9), cervical neuroblastoma (9), extracranial neuroblastoma (9), hyperprolactinemia (8), eisenmenger syndrome (8), normal pressure hydrocephalus (7), adie pupil (7), urticaria pigmentosa (7), endocrine gland cancer (7), anismus (6), diffuse pulmonary fibrosis (6), postgastrectomy syndrome (6), secretory diarrhea (5), space motion sickness (5), hirschsprung disease 1 (5), allergic rhinitis (5), pulmonary hypertension (4), pertussis (4), autonomic nervous system neoplasm (4), acromegaly (4), binswanger's disease (3), rhinitis (3), asthma (3), pheochromocytoma (3), small cell cancer of the lung, somatic (2), cystic fibrosis (2), pancreatic cancer (2), peripheral nervous system neoplasm (1), neuroblastoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.75 RPKM in Colon - Sigmoid
Total median expression: 164.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.10173-0.307 Picture PostScript Text
3' UTR -170.50894-0.191 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000532 - Glucagon_GIP_secretin_VIP
IPR015523 - VIP

Pfam Domains:
PF00123 - Peptide hormone

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2RRH - NMR MuPIT 2RRI - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P01282
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding

Biological Process:
GO:0001878 response to yeast
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007589 body fluid secretion
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0032880 regulation of protein localization
GO:0045087 innate immune response
GO:0045732 positive regulation of protein catabolic process
GO:0048255 mRNA stabilization
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0070459 prolactin secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  AK313950 - Homo sapiens cDNA, FLJ94595.
BC009794 - Homo sapiens vasoactive intestinal peptide, mRNA (cDNA clone MGC:13587 IMAGE:4294373), complete cds.
AK291959 - Homo sapiens cDNA FLJ77165 complete cds, highly similar to Homo sapiens vasoactive intestinal peptide (VIP), transcript variant 2, mRNA.
M36634 - Human vasoactive intestinal peptide (VIP) mRNA, complete cds.
CU679495 - Synthetic construct Homo sapiens gateway clone IMAGE:100018534 5' read VIP mRNA.
HQ447888 - Synthetic construct Homo sapiens clone IMAGE:100071241; CCSB006418_02 vasoactive intestinal peptide (VIP) gene, encodes complete protein.
KJ892378 - Synthetic construct Homo sapiens clone ccsbBroadEn_01772 VIP gene, encodes complete protein.
M54930 - Human vasoactive intestinal peptide and peptide histidine isoleucine mRNA, 3' end.
JD302050 - Sequence 283074 from Patent EP1572962.
JD490725 - Sequence 471749 from Patent EP1572962.
JD354538 - Sequence 335562 from Patent EP1572962.
JD465294 - Sequence 446318 from Patent EP1572962.
JD303042 - Sequence 284066 from Patent EP1572962.
JD171402 - Sequence 152426 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells

Reactome (by CSHL, EBI, and GO)

Protein P01282 (Reactome details) participates in the following event(s):

R-HSA-420233 VIP receptors bind VIP
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000367244.1, ENST00000367244.2, ENST00000367244.3, ENST00000367244.4, ENST00000367244.5, ENST00000367244.6, ENST00000367244.7, NM_003381, P01282, Q5TCY8, Q5TCY9, Q96QK3, uc318ftk.1, uc318ftk.2, VIP_HUMAN
UCSC ID: ENST00000367244.8_5
RefSeq Accession: NM_003381.4
Protein: P01282 (aka VIP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.