Human Gene VKORC1L1 (ENST00000360768.5_5) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: vitamin K epoxide reductase complex subunit 1 like 1, transcript variant 1 (from RefSeq NM_173517.6)
Gencode Transcript: ENST00000360768.5_5
Gencode Gene: ENSG00000196715.7_11
Transcript (Including UTRs)
Position: hg19 chr7:65,338,061-65,424,545 Size: 86,485 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr7:65,338,359-65,419,287 Size: 80,929 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr7:65,338,061-65,424,545)			mRNA (may differ from genome)		Protein (176 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: VKORL_HUMAN DESCRIPTION: RecName: Full=Vitamin K epoxide reductase complex subunit 1-like protein 1; Short=VKORC1-like protein 1; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the VKOR family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001564 Benzo(a)pyrene D003042 Cocaine D003993 Dibutyl Phthalate D008727 Methotrexate D012999 Soman D024483 Vitamin K 3 C044887 beta-methylcholine C006780 bisphenol A more ... click here to view the complete list

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 23.06 RPKM in Adipose - Subcutaneous Total median expression: 389.45 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-192.50	298	-0.646	Picture	PostScript	Text
3' UTR	-1497.40	5258	-0.285	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012932 - VKOR

Pfam Domains:
PF07884 - Vitamin K epoxide reductase family

ModBase Predicted Comparative 3D Structure on Q8N0U8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0016491 oxidoreductase activity GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0048038 quinone binding Biological Process: GO:0017187 peptidyl-glutamic acid carboxylation GO:0034599 cellular response to oxidative stress GO:0042373 vitamin K metabolic process GO:0055114 oxidation-reduction process Cellular Component: GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	HQ447784 - Synthetic construct Homo sapiens clone IMAGE:100071125; CCSB012587_01 vitamin K epoxide reductase complex, subunit 1-like 1 (VKORC1L1) gene, encodes complete protein. BC027734 - Homo sapiens vitamin K epoxide reductase complex, subunit 1-like 1, mRNA (cDNA clone MGC:29720 IMAGE:5093832), complete cds. BX647631 - Homo sapiens mRNA; cDNA DKFZp451K205 (from clone DKFZp451K205). AY423045 - Homo sapiens VKORC1-like protein 1 (VKORC1L1) mRNA, complete cds. AK289522 - Homo sapiens cDNA FLJ76587 complete cds, highly similar to Homo sapiens vitamin K epoxide reductase complex, subunit 1-like 1 (VKORC1L1), mRNA. AK304077 - Homo sapiens cDNA FLJ50107 complete cds, highly similar to Mus musculus vitamin K epoxide reductase complex, subunit 1-like 1, transcript variant 2, mRNA. KJ895689 - Synthetic construct Homo sapiens clone ccsbBroadEn_05083 VKORC1L1 gene, encodes complete protein. JC506661 - Sequence 29 from Patent EP2733220. JC737773 - Sequence 29 from Patent WO2014075939. JD407351 - Sequence 388375 from Patent EP1572962. JD407352 - Sequence 388376 from Patent EP1572962. DQ598612 - Homo sapiens piRNA piR-36678, complete sequence. JD479532 - Sequence 460556 from Patent EP1572962. JD199654 - Sequence 180678 from Patent EP1572962. JD211126 - Sequence 192150 from Patent EP1572962. JD449836 - Sequence 430860 from Patent EP1572962. JD232615 - Sequence 213639 from Patent EP1572962. JD496634 - Sequence 477658 from Patent EP1572962. JD408433 - Sequence 389457 from Patent EP1572962. CR627471 - Homo sapiens mRNA; cDNA DKFZp762H0113 (from clone DKFZp762H0113). AK124688 - Homo sapiens cDNA FLJ42698 fis, clone BRAMY3004377. JD356898 - Sequence 337922 from Patent EP1572962. AK001747 - Homo sapiens cDNA FLJ10885 fis, clone NT2RP4001953. JD507029 - Sequence 488053 from Patent EP1572962. AL137548 - Homo sapiens mRNA; cDNA DKFZp434B1620 (from clone DKFZp434B1620). DQ572761 - Homo sapiens piRNA piR-40873, complete sequence. AK000750 - Homo sapiens cDNA FLJ20743 fis, clone HEP06866. DQ589649 - Homo sapiens piRNA piR-56761, complete sequence. BC007465 - Homo sapiens cDNA clone IMAGE:3828547. JD068966 - Sequence 49990 from Patent EP1572962. JD499658 - Sequence 480682 from Patent EP1572962. JD286711 - Sequence 267735 from Patent EP1572962. JD511544 - Sequence 492568 from Patent EP1572962. JD096050 - Sequence 77074 from Patent EP1572962. JD204892 - Sequence 185916 from Patent EP1572962. JD442083 - Sequence 423107 from Patent EP1572962. JD330901 - Sequence 311925 from Patent EP1572962. JD319530 - Sequence 300554 from Patent EP1572962. JD319531 - Sequence 300555 from Patent EP1572962. JD105747 - Sequence 86771 from Patent EP1572962. JD071046 - Sequence 52070 from Patent EP1572962. JD159130 - Sequence 140154 from Patent EP1572962. JD275928 - Sequence 256952 from Patent EP1572962. JD209368 - Sequence 190392 from Patent EP1572962. JD430752 - Sequence 411776 from Patent EP1572962. JD557980 - Sequence 539004 from Patent EP1572962. JD395355 - Sequence 376379 from Patent EP1572962. JD395356 - Sequence 376380 from Patent EP1572962. JD395357 - Sequence 376381 from Patent EP1572962. DQ594001 - Homo sapiens piRNA piR-60113, complete sequence. JD231999 - Sequence 213023 from Patent EP1572962. JD279366 - Sequence 260390 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-7999 - vitamin K-epoxide cycle Reactome (by CSHL, EBI, and GO) Protein Q8N0U8 (Reactome details) participates in the following event(s): R-HSA-6806647 VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) R-HSA-6806664 Metabolism of vitamin K R-HSA-6806667 Metabolism of fat-soluble vitamins R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: B4E222, E7ETM5, ENST00000360768.1, ENST00000360768.2, ENST00000360768.3, ENST00000360768.4, NM_173517, Q6AHW9, Q6TEK6, Q8N0U8, uc318bsf.1, uc318bsf.2, VKORL_HUMAN UCSC ID: ENST00000360768.5_5 RefSeq Accession: NM_173517.6 Protein: Q8N0U8 (aka VKORL_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.