ID:VPS28_HUMAN DESCRIPTION: RecName: Full=Vacuolar protein sorting-associated protein 28 homolog; Short=H-Vps28; AltName: Full=ESCRT-I complex subunit VPS28; FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and a FAM125/MVB12 protein (FAM125A or -B) in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS37B, VPS37C, FAM125A and FAM125B. Interacts WITH VPS36; the interaction mediates the association with the ESCRT-II complex. Interacts with SNF8 and VPS25. Interacts with CEP55. INTERACTION: Q99816:TSG101; NbExp=3; IntAct=EBI-727424, EBI-346882; SUBCELLULAR LOCATION: Cell membrane. Late endosome membrane; Peripheral membrane protein. SIMILARITY: Belongs to the VPS28 family. SIMILARITY: Contains 1 VPS28 C-terminal domain. SIMILARITY: Contains 1 VPS28 N-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UK41
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0015031 protein transport GO:0016197 endosomal transport GO:0016236 macroautophagy GO:0019058 viral life cycle GO:0031397 negative regulation of protein ubiquitination GO:0032509 endosome transport via multivesicular body sorting pathway GO:0036258 multivesicular body assembly GO:0039702 viral budding via host ESCRT complex GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0045732 positive regulation of protein catabolic process GO:2000397 positive regulation of ubiquitin-dependent endocytosis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
