ID:VPS29_HUMAN DESCRIPTION: RecName: Full=Vacuolar protein sorting-associated protein 29; Short=hVPS29; EC=3.1.3.3; AltName: Full=PEP11 homolog; AltName: Full=Vesicle protein sorting 29; FUNCTION: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). CATALYTIC ACTIVITY: O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate. COFACTOR: Binds 2 zinc ions per subunit (Probable). SUBUNIT: Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain. SIMILARITY: Belongs to the VPS29 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBQ0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0015031 protein transport GO:0016055 Wnt signaling pathway GO:0042147 retrograde transport, endosome to Golgi GO:1990126 retrograde transport, endosome to plasma membrane GO:0010506 regulation of autophagy
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
