ID:VPS51_HUMAN DESCRIPTION: RecName: Full=Vacuolar protein sorting-associated protein 51 homolog; AltName: Full=Another new gene 2 protein; AltName: Full=Protein fat-free homolog; FUNCTION: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. SUBUNIT: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts with STX6. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. SIMILARITY: Belongs to the VPS51 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UID3
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF211187 - JP 2014500723-A/18690: Polycomb-Associated Non-Coding RNAs. MA446764 - JP 2018138019-A/18690: Polycomb-Associated Non-Coding RNAs. JD023327 - Sequence 4351 from Patent EP1572962. JD556140 - Sequence 537164 from Patent EP1572962. AF024631 - Homo sapiens ANG2 (ANG2) mRNA, complete cds. JD517214 - Sequence 498238 from Patent EP1572962. JD030308 - Sequence 11332 from Patent EP1572962. BC010540 - Homo sapiens chromosome 11 open reading frame2, mRNA (cDNA clone MGC:17523 IMAGE:3458443), complete cds. BC010872 - Homo sapiens chromosome 11 open reading frame2, mRNA (cDNA clone IMAGE:3878765). BC007198 - Homo sapiens chromosome 11 open reading frame2, mRNA (cDNA clone MGC:12548 IMAGE:2961456), complete cds. BC017438 - Homo sapiens chromosome 11 open reading frame2, mRNA (cDNA clone MGC:12952 IMAGE:2960352), complete cds. BC006555 - Homo sapiens chromosome 11 open reading frame2, mRNA (cDNA clone IMAGE:2821394), partial cds. AL833818 - Homo sapiens mRNA; cDNA DKFZp434P194 (from clone DKFZp434P194). AF289557 - Homo sapiens clone pp5382 unknown mRNA. JD022075 - Sequence 3099 from Patent EP1572962. JD029490 - Sequence 10514 from Patent EP1572962. BC009285 - Homo sapiens chromosome 11 open reading frame2, mRNA (cDNA clone IMAGE:4299190), partial cds. JD119612 - Sequence 100636 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UID3 (Reactome details) participates in the following event(s):
R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
