ID:VPS52_HUMAN DESCRIPTION: RecName: Full=Vacuolar protein sorting-associated protein 52 homolog; AltName: Full=SAC2 suppressor of actin mutations 2-like protein; FUNCTION: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. SUBUNIT: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts with RAB6A and STX10. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. SIMILARITY: Belongs to the VPS52 family. SEQUENCE CAUTION: Sequence=CAI95619.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N1B4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006896 Golgi to vacuole transport GO:0007041 lysosomal transport GO:0010668 ectodermal cell differentiation GO:0015031 protein transport GO:0032456 endocytic recycling GO:0042147 retrograde transport, endosome to Golgi GO:0048611 embryonic ectodermal digestive tract development
AK222867 - Homo sapiens mRNA for suppressor of actin mutations 2-like isoform a variant, clone: HEP15548. BC032108 - Homo sapiens vacuolar protein sorting 52 homolog (S. cerevisiae), mRNA (cDNA clone MGC:23328 IMAGE:4644275), complete cds. BC040114 - Homo sapiens vacuolar protein sorting 52 homolog (S. cerevisiae), mRNA (cDNA clone MGC:48686 IMAGE:5755265), complete cds. AK093057 - Homo sapiens cDNA FLJ35738 fis, clone TESTI2003692, highly similar to Rattus norvegicus mRNA for ARE1 protein. AK001725 - Homo sapiens cDNA FLJ10863 fis, clone NT2RP4001575, highly similar to Vacuolar protein sorting protein 52. AL390171 - Homo sapiens mRNA; cDNA DKFZp547I194 (from clone DKFZp547I194). AX775737 - Sequence 7 from Patent WO03048202. JD390645 - Sequence 371669 from Patent EP1572962. BC013012 - Homo sapiens vacuolar protein sorting 52 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3605512), **** WARNING: chimeric clone ****. JD566807 - Sequence 547831 from Patent EP1572962. JD291127 - Sequence 272151 from Patent EP1572962. JD221489 - Sequence 202513 from Patent EP1572962. JD220086 - Sequence 201110 from Patent EP1572962. JD218811 - Sequence 199835 from Patent EP1572962. JD465985 - Sequence 447009 from Patent EP1572962. JD454888 - Sequence 435912 from Patent EP1572962. AK299563 - Homo sapiens cDNA FLJ55499 complete cds, highly similar to Vacuolar protein sorting protein 52. JD501814 - Sequence 482838 from Patent EP1572962. JD528811 - Sequence 509835 from Patent EP1572962. JD290021 - Sequence 271045 from Patent EP1572962. AK297935 - Homo sapiens cDNA FLJ54452 complete cds, highly similar to Vacuolar protein sorting protein 52. AJ006026 - Homo sapiens mRNA for ARE1-like protein. JD554294 - Sequence 535318 from Patent EP1572962. JD391240 - Sequence 372264 from Patent EP1572962. JD365615 - Sequence 346639 from Patent EP1572962. JD149911 - Sequence 130935 from Patent EP1572962. JD020325 - Sequence 1349 from Patent EP1572962. JD021665 - Sequence 2689 from Patent EP1572962. JD031297 - Sequence 12321 from Patent EP1572962. AK304080 - Homo sapiens cDNA FLJ58349 complete cds, highly similar to Vacuolar protein sorting protein 52. AK300430 - Homo sapiens cDNA FLJ60156 complete cds, highly similar to Vacuolar protein sorting protein 52. AK300308 - Homo sapiens cDNA FLJ58858 complete cds, highly similar to Vacuolar protein sorting protein 52. JD406184 - Sequence 387208 from Patent EP1572962. JD276753 - Sequence 257777 from Patent EP1572962. JD317759 - Sequence 298783 from Patent EP1572962. JD488891 - Sequence 469915 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N1B4 (Reactome details) participates in the following event(s):
R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
