Human Gene VWA5B2 (ENST00000273794.5_3) from GENCODE V47lift37
  Description: von Willebrand factor A domain containing 5B2, transcript variant 10 (from RefSeq NM_001390847.1)
Gencode Transcript: ENST00000273794.5_3
Gencode Gene: ENSG00000145198.15_7
Transcript (Including UTRs)
   Position: hg19 chr3:183,951,204-183,960,071 Size: 8,868 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr3:183,951,491-183,959,826 Size: 8,336 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:183,951,204-183,960,071)mRNA (may differ from genome)Protein (1024 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: E9PF42_HUMAN
DESCRIPTION: SubName: Full=von Willebrand factor A domain-containing protein 5B2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.22 RPKM in Adrenal Gland
Total median expression: 241.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.90166-0.385 Picture PostScript Text
3' UTR -67.60245-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002035 - VWF_A

Pfam Domains:
PF13768 - von Willebrand factor type A domain

SCOP Domains:
53300 - vWA-like

ModBase Predicted Comparative 3D Structure on E9PF42
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  BC136609 - Homo sapiens von Willebrand factor A domain containing 5B2, mRNA (cDNA clone MGC:168222 IMAGE:9020599), complete cds.
BC009862 - Homo sapiens hypothetical protein BC009862, mRNA (cDNA clone IMAGE:3936401), partial cds.
JD268359 - Sequence 249383 from Patent EP1572962.
AK293885 - Homo sapiens cDNA FLJ56885 complete cds.
JD519467 - Sequence 500491 from Patent EP1572962.
BC001200 - Homo sapiens von Willebrand factor A domain containing 5B2, mRNA (cDNA clone IMAGE:3356192), partial cds.
JD322501 - Sequence 303525 from Patent EP1572962.
AL834499 - Homo sapiens mRNA; cDNA DKFZp761K032 (from clone DKFZp761K032).
JD050402 - Sequence 31426 from Patent EP1572962.
JD546363 - Sequence 527387 from Patent EP1572962.
JD136473 - Sequence 117497 from Patent EP1572962.
JD359897 - Sequence 340921 from Patent EP1572962.
JD302496 - Sequence 283520 from Patent EP1572962.
JD304107 - Sequence 285131 from Patent EP1572962.
JD311597 - Sequence 292621 from Patent EP1572962.
JD162521 - Sequence 143545 from Patent EP1572962.
JD412895 - Sequence 393919 from Patent EP1572962.
JD097835 - Sequence 78859 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PF42, E9PF42_HUMAN, ENST00000273794.1, ENST00000273794.2, ENST00000273794.3, ENST00000273794.4, NM_001390847, uc317jcu.1, uc317jcu.2, VWA5B2
UCSC ID: ENST00000273794.5_3
RefSeq Accession: NM_001390847.1
Protein: E9PF42

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.