Human Gene INTS14 (ENST00000313182.7_8) from GENCODE V47lift37
  Description: integrator complex subunit 14, transcript variant 6 (from RefSeq NM_001394796.1)
Gencode Transcript: ENST00000313182.7_8
Gencode Gene: ENSG00000138614.16_14
Transcript (Including UTRs)
   Position: hg19 chr15:65,871,095-65,903,469 Size: 32,375 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr15:65,871,746-65,899,718 Size: 27,973 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:65,871,095-65,903,469)mRNA (may differ from genome)Protein (518 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
ReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: VWA9_HUMAN
DESCRIPTION: RecName: Full=von Willebrand factor A domain-containing protein 9;
TISSUE SPECIFICITY: Strongly expressed in numerous cancer cells compared with their non-cancerous counterparts (lung, prostate, colon, stomach and skin).
SIMILARITY: Belongs to the VWA9 family.
SIMILARITY: Contains 1 VWFA domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.07 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 447.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.2096-0.263 Picture PostScript Text
3' UTR -171.00651-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002035 - VWF_A

Pfam Domains:
PF13519 - von Willebrand factor type A domain
PF19435 - Integrator complex subunit 14

SCOP Domains:
53300 - vWA-like

ModBase Predicted Comparative 3D Structure on Q96SY0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0042795 snRNA transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  LF208542 - JP 2014500723-A/16045: Polycomb-Associated Non-Coding RNAs.
AL136662 - Homo sapiens mRNA; cDNA DKFZp564O1664 (from clone DKFZp564O1664).
BC007991 - Homo sapiens chromosome 15 open reading frame 44, mRNA (cDNA clone MGC:4587 IMAGE:3140504), complete cds.
AK027475 - Homo sapiens cDNA FLJ14569 fis, clone NT2RM4000514.
JD364434 - Sequence 345458 from Patent EP1572962.
JD307924 - Sequence 288948 from Patent EP1572962.
AK296134 - Homo sapiens cDNA FLJ55475 complete cds.
JD263568 - Sequence 244592 from Patent EP1572962.
AK301033 - Homo sapiens cDNA FLJ50701 complete cds.
AK301742 - Homo sapiens cDNA FLJ50723 complete cds.
AK293207 - Homo sapiens cDNA FLJ52585 complete cds.
JD170259 - Sequence 151283 from Patent EP1572962.
AK301222 - Homo sapiens cDNA FLJ50705 complete cds.
JD309500 - Sequence 290524 from Patent EP1572962.
JD565438 - Sequence 546462 from Patent EP1572962.
JD424996 - Sequence 406020 from Patent EP1572962.
KJ899677 - Synthetic construct Homo sapiens clone ccsbBroadEn_09071 C15orf44 gene, encodes complete protein.
AB527114 - Synthetic construct DNA, clone: pF1KE0007, Homo sapiens C15orf44 gene for chromosome 15 open reading frame 44, without stop codon, in Flexi system.
AM392914 - Synthetic construct Homo sapiens clone IMAGE:100001977 for hypothetical protein (C15orf44 gene).
LF377492 - JP 2014500723-A/184995: Polycomb-Associated Non-Coding RNAs.
JD020674 - Sequence 1698 from Patent EP1572962.
JD035200 - Sequence 16224 from Patent EP1572962.
LF377489 - JP 2014500723-A/184992: Polycomb-Associated Non-Coding RNAs.
CU675887 - Synthetic construct Homo sapiens gateway clone IMAGE:100019756 5' read C15orf44 mRNA.
LF377486 - JP 2014500723-A/184989: Polycomb-Associated Non-Coding RNAs.
AK310857 - Homo sapiens cDNA, FLJ17899.
LF377485 - JP 2014500723-A/184988: Polycomb-Associated Non-Coding RNAs.
BC037823 - Homo sapiens chromosome 15 open reading frame 44, mRNA (cDNA clone IMAGE:4800066), complete cds.
MA444119 - JP 2018138019-A/16045: Polycomb-Associated Non-Coding RNAs.
MA613069 - JP 2018138019-A/184995: Polycomb-Associated Non-Coding RNAs.
MA613066 - JP 2018138019-A/184992: Polycomb-Associated Non-Coding RNAs.
MA613063 - JP 2018138019-A/184989: Polycomb-Associated Non-Coding RNAs.
MA613062 - JP 2018138019-A/184988: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96SY0 (Reactome details) participates in the following event(s):

R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B4DDI6, B4DVD5, C15orf44 , ENST00000313182.1, ENST00000313182.2, ENST00000313182.3, ENST00000313182.4, ENST00000313182.5, ENST00000313182.6, INT14_HUMAN, INTS14 , NM_001394796, Q49AH8, Q96HX5, Q96SY0, Q9H0S5, uc317pjb.1, uc317pjb.2, VWA9
UCSC ID: ENST00000313182.7_8
RefSeq Accession: NM_001394796.1
Protein: Q96SY0 (aka VWA9_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.