ID:WBP4_HUMAN DESCRIPTION: RecName: Full=WW domain-binding protein 4; Short=WBP-4; AltName: Full=Formin-binding protein 21; AltName: Full=WW domain-containing-binding protein 4; FUNCTION: Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. SUBUNIT: Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1. Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68 (By similarity). Interacts via the WW domains with the Pro-rich domains of WBP11. SUBCELLULAR LOCATION: Nucleus speckle. DOMAIN: The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (By similarity). SIMILARITY: Contains 1 matrin-type zinc finger. SIMILARITY: Contains 2 WW domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75554
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK000979 - Homo sapiens cDNA FLJ10117 fis, clone HEMBA1002810, highly similar to Homo sapiens formin binding protein 21 mRNA. AK314525 - Homo sapiens cDNA, FLJ95344, highly similar to Homo sapiens WW domain binding protein 4 (formin binding protein 21) (WBP4), mRNA. AK001557 - Homo sapiens cDNA FLJ10695 fis, clone NT2RP3000403, highly similar to WW domain-binding protein 4. AK297536 - Homo sapiens cDNA FLJ52917 complete cds, highly similar to WW domain-binding protein 4. BC108310 - Homo sapiens WW domain binding protein 4 (formin binding protein 21), mRNA (cDNA clone MGC:117310 IMAGE:6014541), complete cds. AF071185 - Homo sapiens formin binding protein 21 mRNA, complete cds. BC104879 - Homo sapiens WW domain binding protein 4 (formin binding protein 21), mRNA (cDNA clone MGC:132539 IMAGE:8143882), complete cds. JD310533 - Sequence 291557 from Patent EP1572962. AB385558 - Synthetic construct DNA, clone: pF1KB8002, Homo sapiens WBP4 gene for WW domain-binding protein 4, complete cds, without stop codon, in Flexi system. KJ893250 - Synthetic construct Homo sapiens clone ccsbBroadEn_02644 WBP4 gene, encodes complete protein. JD088589 - Sequence 69613 from Patent EP1572962. JD563842 - Sequence 544866 from Patent EP1572962. JD371396 - Sequence 352420 from Patent EP1572962. JD433859 - Sequence 414883 from Patent EP1572962. JD334082 - Sequence 315106 from Patent EP1572962. JD168421 - Sequence 149445 from Patent EP1572962. JD243001 - Sequence 224025 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75554 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
