Human Gene WDHD1 (ENST00000360586.8_7) from GENCODE V47lift37

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Description: WD repeat and HMG-box DNA binding protein 1, transcript variant 1 (from RefSeq NM_007086.4)
Gencode Transcript: ENST00000360586.8_7
Gencode Gene: ENSG00000198554.12_13
Transcript (Including UTRs)
Position: hg19 chr14:55,405,667-55,493,817 Size: 88,151 Total Exon Count: 26 Strand: -
Coding Region
Position: hg19 chr14:55,408,208-55,493,505 Size: 85,298 Coding Exon Count: 25

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:55,405,667-55,493,817)			mRNA (may differ from genome)		Protein (1129 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: WDHD1_HUMAN DESCRIPTION: RecName: Full=WD repeat and HMG-box DNA-binding protein 1; AltName: Full=Acidic nucleoplasmic DNA-binding protein 1; Short=And-1; FUNCTION: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. SUBUNIT: Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2. SUBCELLULAR LOCATION: Nucleus, nucleoplasm (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 HMG box DNA-binding domain. SIMILARITY: Contains 7 WD repeats.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: WDHD1 Diseases sorted by gene-association score: trench fever (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D016604 Aflatoxin B1 D002117 Calcitriol D002251 Carbon Tetrachloride D002509 Cephaloridine D002945 Cisplatin D003300 Copper D019327 Copper Sulfate D003375 Coumestrol D016572 Cyclosporine D003993 Dibutyl Phthalate D004026 Dieldrin D004958 Estradiol D058185 Magnetite Nanoparticles C558013 NSC 689534 D011374 Progesterone D011794 Quercetin D012999 Soman D004113 Succimer D013739 Testosterone D014212 Tretinoin C006780 bisphenol A C018021 cobaltous chloride C488369 dasatinib C045651 epigallocatechin gallate C027373 potassium chromate(VI) C059514 resveratrol C014215 tetrahydropalmatine C015559 trimellitic anhydride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.58 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 43.69 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-30.90	88	-0.351	Picture	PostScript	Text
3' UTR	-608.20	2541	-0.239	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR022100 - DUF3639
IPR009071 - HMG_superfamily
IPR013979 - TIF2A_beta_prop-like
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat
PF08662 - Eukaryotic translation initiation factor eIF2A
PF12341 - Minichromosome loss protein, Mcl1, middle region
PF12894 - Anaphase-promoting complex subunit 4 WD40 domain

SCOP Domains:
47095 - HMG-box
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2D7L - NMR MuPIT

ModBase Predicted Comparative 3D Structure on O75717


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003723 RNA binding GO:0005515 protein binding GO:0070063 RNA polymerase binding Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006396 RNA processing GO:0033044 regulation of chromosome organization GO:0070829 heterochromatin maintenance Cellular Component: GO:0000775 chromosome, centromeric region GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AJ006266 - Homo sapiens mRNA for AND-1 protein. AK001585 - Homo sapiens cDNA FLJ10723 fis, clone NT2RP3001155, highly similar to WD repeat and HMG-box DNA-binding protein 1. BC063041 - Homo sapiens WD repeat and HMG-box DNA binding protein 1, mRNA (cDNA clone MGC:65069 IMAGE:6514641), complete cds. AK001538 - Homo sapiens cDNA FLJ10676 fis, clone NT2RP2006464, highly similar to WD repeat and HMG-box DNA-binding protein 1. AK293005 - Homo sapiens cDNA FLJ78476 complete cds, highly similar to Homo sapiens WD repeat and HMG-box DNA binding protein 1 (WDHD1), transcript variant 1, mRNA. AY517556 - Homo sapiens hypothetical rhabdomyosarcoma antigen MU-RMS-40.1 mRNA, partial cds. AK001620 - Homo sapiens cDNA FLJ10758 fis, clone NT2RP3004594, highly similar to WD repeat and HMG-box DNA-binding protein 1. JD176079 - Sequence 157103 from Patent EP1572962. JD353826 - Sequence 334850 from Patent EP1572962. JD269187 - Sequence 250211 from Patent EP1572962. BC000622 - Homo sapiens WD repeat and HMG-box DNA binding protein 1, mRNA (cDNA clone IMAGE:3346434), partial cds. BC005040 - Homo sapiens WD repeat and HMG-box DNA binding protein 1, mRNA (cDNA clone IMAGE:3615423), partial cds. BC043349 - Homo sapiens WD repeat and HMG-box DNA binding protein 1, mRNA (cDNA clone IMAGE:5403530), partial cds.

Other Names for This Gene


	Alternate Gene Symbols: AND1, C9JW18, ENST00000360586.1, ENST00000360586.2, ENST00000360586.3, ENST00000360586.4, ENST00000360586.5, ENST00000360586.6, ENST00000360586.7, F6W0U7, NM_007086, O75717, uc318bqd.1, uc318bqd.2, WDHD1 , WDHD1_HUMAN UCSC ID: ENST00000360586.8_7 RefSeq Accession: NM_007086.4 Protein: O75717 (aka WDHD1_HUMAN or WDH1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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