ID:WDR33_HUMAN DESCRIPTION: RecName: Full=pre-mRNA 3' end processing protein WDR33; AltName: Full=WD repeat-containing protein 33; AltName: Full=WD repeat-containing protein WDC146; FUNCTION: Essential for both cleavage and polyadenylation of pre- mRNA 3' ends. SUBUNIT: Component of the cleavage and polyadenylation specificity factor (CPSF) module of the pre-mRNA 3' end processing complex. Interacts with CPSF3/CPSF73. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Most highly expressed in testis. SIMILARITY: Contains 1 collagen-like domain. SIMILARITY: Contains 7 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9C0J8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF210997 - JP 2014500723-A/18500: Polycomb-Associated Non-Coding RNAs. JD024186 - Sequence 5210 from Patent EP1572962. JD033785 - Sequence 14809 from Patent EP1572962. BC010283 - Homo sapiens WD repeat domain 33, mRNA (cDNA clone IMAGE:3048789). JA482243 - Sequence 226 from Patent WO2011072091. JE980535 - Sequence 226 from Patent EP2862929. AL834365 - Homo sapiens mRNA; cDNA DKFZp762F0712 (from clone DKFZp762F0712). AB044749 - Homo sapiens mRNA for WDC146, complete cds. AK098003 - Homo sapiens cDNA FLJ40684 fis, clone THYMU2023900, weakly similar to Collagen alpha 1(XI) chain. JD136539 - Sequence 117563 from Patent EP1572962. JD272486 - Sequence 253510 from Patent EP1572962. JD174575 - Sequence 155599 from Patent EP1572962. JD331177 - Sequence 312201 from Patent EP1572962. BC169264 - Synthetic construct Homo sapiens clone IMAGE:9093284 WD repeat domain 33 isoform 1 (WDR33) gene, partial cds. DQ593904 - Homo sapiens piRNA piR-34016, complete sequence. BC169263 - Synthetic construct Homo sapiens clone IMAGE:9093282 WD repeat domain 33 isoform 1 (WDR33) gene, partial cds. BC169262 - Synthetic construct Homo sapiens clone IMAGE:9093283 WD repeat domain 33 isoform 1 (WDR33) gene, partial cds. JA482245 - Sequence 228 from Patent WO2011072091. JE980537 - Sequence 228 from Patent EP2862929. BC068484 - Homo sapiens WD repeat domain 33, mRNA (cDNA clone IMAGE:30345533), complete cds. AK002156 - Homo sapiens cDNA FLJ11294 fis, clone PLACE1009708. BC108671 - Homo sapiens cDNA clone IMAGE:6151131, containing frame-shift errors. AK223319 - Homo sapiens mRNA for WD repeat domain 33 isoform 2 variant, clone: TMS08632. JA482244 - Sequence 227 from Patent WO2011072091. JE980536 - Sequence 227 from Patent EP2862929. BC013990 - Homo sapiens WD repeat domain 33, mRNA (cDNA clone IMAGE:3640219), complete cds. KJ894192 - Synthetic construct Homo sapiens clone ccsbBroadEn_03586 WDR33 gene, encodes complete protein. BC005401 - Homo sapiens WD repeat domain 33, mRNA (cDNA clone IMAGE:3839672), partial cds. JD468649 - Sequence 449673 from Patent EP1572962. MA446574 - JP 2018138019-A/18500: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9C0J8 (Reactome details) participates in the following event(s):
R-HSA-72231 Cleavage and Polyadenylation R-HSA-77589 Recognition of AAUAAA sequence by CPSF R-HSA-72185 mRNA polyadenylation R-HSA-77594 Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-77590 Recruitment of CstF to the CPSF Bound Pre-mRNA R-HSA-77592 Cleavage of Intronless Pre-mRNA at 3'-end R-HSA-77593 Cleavage and polyadenylation of Intronless Pre-mRNA R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-156661 Formation of Exon Junction Complex R-HSA-77591 Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-77595 Processing of Intronless Pre-mRNAs R-HSA-72187 mRNA 3'-end processing R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-75067 Processing of Capped Intronless Pre-mRNA R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
