Human Gene WDR41 (ENST00000296679.9_7) from GENCODE V47lift37
  Description: WD repeat domain 41 (from RefSeq NM_018268.4)
Gencode Transcript: ENST00000296679.9_7
Gencode Gene: ENSG00000164253.14_17
Transcript (Including UTRs)
   Position: hg19 chr5:76,726,758-76,788,141 Size: 61,384 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr5:76,728,960-76,788,045 Size: 59,086 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:76,726,758-76,788,141)mRNA (may differ from genome)Protein (459 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: WDR41_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 41;
SIMILARITY: Contains 6 WD repeats.
SEQUENCE CAUTION: Sequence=AAO06948.1; Type=Frameshift; Positions=188;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: WDR41
Diseases sorted by gene-association score: dementia, frontotemporal (1), amyotrophic lateral sclerosis 1 (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.91 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 281.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.0096-0.385 Picture PostScript Text
3' UTR -498.502202-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9HAD4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity

Biological Process:
GO:0006914 autophagy
GO:0010506 regulation of autophagy

Cellular Component:
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0032045 guanyl-nucleotide exchange factor complex
GO:1990316 ATG1/ULK1 kinase complex


-  Descriptions from all associated GenBank mRNAs
  AK023977 - Homo sapiens cDNA FLJ13915 fis, clone Y79AA1000328, weakly similar to SEL-10 PROTEIN.
AL834138 - Homo sapiens mRNA; cDNA DKFZp434J2114 (from clone DKFZp434J2114).
AF115511 - Homo sapiens MSTP048 (MST048) mRNA, complete cds.
BC040241 - Homo sapiens WD repeat domain 41, mRNA (cDNA clone MGC:5405 IMAGE:3447269), complete cds.
LF384944 - JP 2014500723-A/192447: Polycomb-Associated Non-Coding RNAs.
AK001766 - Homo sapiens cDNA FLJ10904 fis, clone OVARC1000013, weakly similar to APOPTOTIC PROTEASE ACTIVATING FACTOR 1.
JD108386 - Sequence 89410 from Patent EP1572962.
JD280395 - Sequence 261419 from Patent EP1572962.
JD278381 - Sequence 259405 from Patent EP1572962.
JD087216 - Sequence 68240 from Patent EP1572962.
AK021855 - Homo sapiens cDNA FLJ11793 fis, clone HEMBA1006130, weakly similar to SEL-10 PROTEIN.
JD315759 - Sequence 296783 from Patent EP1572962.
JD304561 - Sequence 285585 from Patent EP1572962.
AK293316 - Homo sapiens cDNA FLJ50441 complete cds, highly similar to WD repeat protein 41.
JD120267 - Sequence 101291 from Patent EP1572962.
AK300058 - Homo sapiens cDNA FLJ50659 complete cds, highly similar to WD repeat protein 41.
JD095046 - Sequence 76070 from Patent EP1572962.
JD056573 - Sequence 37597 from Patent EP1572962.
JD377310 - Sequence 358334 from Patent EP1572962.
AK304329 - Homo sapiens cDNA FLJ61203 complete cds, highly similar to WD repeat protein 41.
BC001807 - Homo sapiens cDNA clone IMAGE:3354734, containing frame-shift errors.
JF432800 - Synthetic construct Homo sapiens clone IMAGE:100074117 WD repeat domain 41 (WDR41) gene, encodes complete protein.
KJ894170 - Synthetic construct Homo sapiens clone ccsbBroadEn_03564 WDR41 gene, encodes complete protein.
KU178690 - Homo sapiens WD repeat domain 41 isoform 1 (WDR41) mRNA, partial cds.
KU178691 - Homo sapiens WD repeat domain 41 isoform 2 (WDR41) mRNA, partial cds, alternatively spliced.
AK295249 - Homo sapiens cDNA FLJ50520 complete cds, highly similar to WD repeat protein 41.
KJ906223 - Synthetic construct Homo sapiens clone ccsbBroadEn_15893 WDR41 gene, encodes complete protein.
JD025570 - Sequence 6594 from Patent EP1572962.
JD024550 - Sequence 5574 from Patent EP1572962.
AK296423 - Homo sapiens cDNA FLJ50556 complete cds, highly similar to WD repeat protein 41.
JD027536 - Sequence 8560 from Patent EP1572962.
JD030019 - Sequence 11043 from Patent EP1572962.
CU691838 - Synthetic construct Homo sapiens gateway clone IMAGE:100019496 5' read WDR41 mRNA.
JD156184 - Sequence 137208 from Patent EP1572962.
JD140769 - Sequence 121793 from Patent EP1572962.
MA620521 - JP 2018138019-A/192447: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DT55, ENST00000296679.1, ENST00000296679.2, ENST00000296679.3, ENST00000296679.4, ENST00000296679.5, ENST00000296679.6, ENST00000296679.7, ENST00000296679.8, MSTP048, NM_018268, Q7Z792, Q8IWG3, Q8IXA9, Q8NDA7, Q9HAD4, Q9NV62, uc317lvx.1, uc317lvx.2, WDR41 , WDR41_HUMAN
UCSC ID: ENST00000296679.9_7
RefSeq Accession: NM_018268.4
Protein: Q9HAD4 (aka WDR41_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.