ID:WDR48_HUMAN DESCRIPTION: RecName: Full=WD repeat-containing protein 48; AltName: Full=USP1-associated factor 1; AltName: Full=WD repeat endosomal protein; AltName: Full=p80; FUNCTION: Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1. SUBUNIT: Interacts with USP1, USP12 and USP46. Interacts with Saimiriine herpesvirus TIP protein. Interacts with papillomavirus HPV11 E1 protein. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Lysosome. Note=Mainly cytoplasmic. In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: N-terminal WD region interacts with TIP and C-terminal region mediates lysosomal localization. The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46. SIMILARITY: Belongs to the WD repeat WDR48 family. SIMILARITY: Contains 8 WD repeats. SEQUENCE CAUTION: Sequence=AAH37168.1; Type=Erroneous initiation; Sequence=BAA95973.2; Type=Erroneous initiation; Sequence=CAH56182.1; Type=Erroneous initiation; Sequence=CAH56300.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TAF3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
Biological Process: GO:0000724 double-strand break repair via homologous recombination GO:0006974 cellular response to DNA damage stimulus GO:0007283 spermatogenesis GO:0007338 single fertilization GO:0008584 male gonad development GO:0016032 viral process GO:0016579 protein deubiquitination GO:0035264 multicellular organism growth GO:0042769 DNA damage response, detection of DNA damage GO:0043588 skin development GO:0048568 embryonic organ development GO:0048705 skeletal system morphogenesis GO:0048872 homeostasis of number of cells GO:0050679 positive regulation of epithelial cell proliferation GO:0072520 seminiferous tubule development GO:1902525 regulation of protein monoubiquitination
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
